Dementia is a rapidly rising global health crisis that silently disables families and ends lives
and livelihoods around the world. To date, however, no early biomarkers or effective …

The Pliocene climate is globally warm and characterised by high atmospheric carbon
dioxide concentrations, yet the terrestrial and marine scientific communities have gathered …

Interleukin (IL)‐17 is an emerging target for inflammatory skin disorders. Given the remarkable
success of its therapeutic inhibition in psoriasis, the pathogenic role of this cytokine is …

… To uncover the full immune diversity at the brain’s borders, together with a detailed
analysis of its macrophage populations, we isolated brains or individual border regions from …

Alzheimer’s disease (AD) is characterized by synaptic loss, which can result from
dysfunctional microglial phagocytosis and complement activation. However, what signals drive …

Macrophages are highly heterogeneous tissue-resident immune cells that perform a variety
of tissue-supportive functions. The current paradigm dictates that intestinal macrophages are …

We report germline loss-of-function mutations in SPRED1 in a newly identified autosomal
dominant human disorder. SPRED1 is a member of the SPROUTY/SPRED family 1 of proteins …

A model has been developed allowing to simulate the flow boiling process of a hydrocarbon
feedstock. For the calculation of the different horizontal two-phase flow regimes that evolve …

Background Vitiligo is a pigmentary disorder affecting at least 1% of the total population.
Although the disease does not produce direct physical impairment, it may considerably …

Although stakeholder management is seen as one of the main success factors of Public–Private
Partnerships (PPPs), to date, limited research has investigated actual stakeholder …