Objectives : Our aim was to investigate in a prospective study a potential role of C-reactive
protein (CRP) in predicting the outcome in pulmonary arterial hypertension (PAH) and chronic …

Pulmonary veno-occlusive disease (PVOD) is an uncommon form of pulmonary hypertension
(PH) characterized by progressive obstruction of small pulmonary veins and a dismal …

Background— The metabolic syndrome is typified by obesity, dyslipidemia, diabetes,
hypertension, increased oxidative stress, and accelerated atherosclerosis. Paraoxonase1 (PON1), …

Background— Obesity-associated dyslipidemia in humans is associated with increased low-density
lipoprotein (LDL) oxidation. Mice with combined leptin and LDL receptor deficiency …

Background—Atherosclerosis is characterized by an early inflammatory response involving
proinflammatory mediators such as platelet-activating factor (PAF)-like phospholipids, which …

Deficient angiogenesis and systemic inflammation could be involved in the pathophysiology
of chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to characterise the …

Background Pulmonary endarterectomy (PEA), pulmonary arterial hypertension (PAH)
therapy and balloon pulmonary angioplasty (BPA) are currently accepted therapies for chronic …

Background Disuse and/or local inflammation in the muscle cannot be excluded as potential
influences for the decreased muscle force in patients hospitalised due to an acute chronic …

Background— Weight loss in obese insulin-resistant but not in insulin-sensitive persons
reduces coronary heart disease risk. To what extent changes in gene expression are related to …

Background: Senescent cells (SCs) are involved in proliferative disorders, but their role in
pulmonary hypertension remains undefined. We investigated SCs in patients with pulmonary …