Rationale: The treatment effect of golimumab, a human monoclonal antibody against tumor
necrosis factor (TNF)-α, in severe persistent asthma is unknown. Objectives: To assess the …

Rationale: Chronic obstructive pulmonary disease (COPD) is a progressive, smoking-related,
inflammatory lung disease in which tumor necrosis factor-α is overexpressed and has …

Initiation of T-lymphocyte proliferation by mitogen or antigen involves a cascade of gene
activation events. Thus, by the time mitogen-activated T cells have reached the G 1 /S interface, …

Sarcoidosis is characterised by non-caseating granulomas that secrete pro-inflammatory
cytokines, including interleukin (IL)-12, IL-23, and tumour necrosis factor (TNF)-α. Ustekinumab …

While a number of oncogenes are expressed in a cell cycle-dependent manner, their role in
the control of cell proliferation can only be established by a direct functional assay. The c-…

Burkitt lymphoma cells carrying either a rearranged or unrearranged c-myc oncogene were
examined with the use of probes from the 5′ exon and for the second and third exon of the …

Comparative nucleotide sequence analysis of a rearranged c-myc gene in a murine
plasmacytoma and c-myc cDNA from normal spleen reveals that chromosomal translocation in the …

NIARD (non-immunoglobulin-associated rearranging DNA) is located on mouse chromosome
15 at the break point of a commonly observed translocation event involving chromosomes …

We have investigated whether the translocated and the untranslocated human c-myc oncogenes
of Burkitt lymphoma cells are equally or differentially expressed in host mouse B cells. …

In an effort to study in detail the nature of the protein product of the human protooncogene c-myc,
we have expressed the gene at high levels in Escherichia coli. The c-myc coding …