Biologics, including omalizumab, mepolizumab, benralizumab, and dupilumab, targeting
downstream IgE, cytokines IL-5, and IL-4/13, respectively, have shown promising effects in …

High-risk patients requiring hospitalization for severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) infection are those over 60 years old, males, obese, smokers, and those …

Patients with severe refractory asthma present a challenging clinical conundrum for
practicing clinicians. Biologics that target key mediators in the type 2 inflammation cascade, …

The small airways dysfunction (SAD) asthma phenotype is characterised by narrowing of
airways < 2 mm in diameter between generations 8 and 23 of the bronchial tree. Recently, this …

Patients with severe chronic rhinosinusitis with nasal polyps represent an unmet clinical need
in terms of recurrent disease despite current medical and surgical therapy. Targeting type …

Dr. Chan has nothing to disclose. 22 Dr. Kuo reports personal fees from Pfizer, personal fees
from AstraZeneca, personal fees from Chiesi 23 outside the submitted work. 24 Dr Lipworth …

Background Mucus plugging is recognized as a contributory factor to airway obstruction and
symptoms in persistent asthma. Objective We aimed to determine phenotypic associations …

Introduction Forced vital capacity (FVC) is often preserved in severe asthma unless there is
evidence of either airway remodelling or air trapping. Area under the reactance curve (AX) …

Repeatability of impulse oscillometry in severe asthma is unknown. This study reports on
medium term repeatability for IOS and proposes values for within subject biological …

Background A recent study demonstrated a significant correlation between bronchial biopsy
airway remodeling and quantitative computed tomography looking at bronchial wall …