User profiles for Rory Chan
Rory ChanUniversity of Dundee Verified email at dundee.ac.uk Cited by 611 |
[HTML][HTML] Targeting downstream type 2 cytokines or upstream epithelial alarmins for severe asthma
Biologics, including omalizumab, mepolizumab, benralizumab, and dupilumab, targeting
downstream IgE, cytokines IL-5, and IL-4/13, respectively, have shown promising effects in …
downstream IgE, cytokines IL-5, and IL-4/13, respectively, have shown promising effects in …
Weathering the cytokine storm in susceptible patients with severe SARS-CoV-2 infection
High-risk patients requiring hospitalization for severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) infection are those over 60 years old, males, obese, smokers, and those …
2 (SARS-CoV-2) infection are those over 60 years old, males, obese, smokers, and those …
Pragmatic clinical perspective on biologics for severe refractory type 2 asthma
Patients with severe refractory asthma present a challenging clinical conundrum for
practicing clinicians. Biologics that target key mediators in the type 2 inflammation cascade, …
practicing clinicians. Biologics that target key mediators in the type 2 inflammation cascade, …
[HTML][HTML] Impact of biologic therapy on the small airways asthma phenotype
R Chan, BJ Lipworth - Lung, 2022 - Springer
The small airways dysfunction (SAD) asthma phenotype is characterised by narrowing of
airways < 2 mm in diameter between generations 8 and 23 of the bronchial tree. Recently, this …
airways < 2 mm in diameter between generations 8 and 23 of the bronchial tree. Recently, this …
The choice of biologics in patients with severe chronic rhinosinusitis with nasal polyps
BJ Lipworth, R Chan - The Journal of Allergy and Clinical Immunology: In …, 2021 - Elsevier
Patients with severe chronic rhinosinusitis with nasal polyps represent an unmet clinical need
in terms of recurrent disease despite current medical and surgical therapy. Targeting type …
in terms of recurrent disease despite current medical and surgical therapy. Targeting type …
[PDF][PDF] Disconnect between effects of mepolizumab on severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps
Dr. Chan has nothing to disclose. 22 Dr. Kuo reports personal fees from Pfizer, personal fees
from AstraZeneca, personal fees from Chiesi 23 outside the submitted work. 24 Dr Lipworth …
from AstraZeneca, personal fees from Chiesi 23 outside the submitted work. 24 Dr Lipworth …
[HTML][HTML] Clinical associations of mucus plugging in moderate to severe asthma
R Chan, C Duraikannu, B Lipworth - The Journal of Allergy and Clinical …, 2023 - Elsevier
Background Mucus plugging is recognized as a contributory factor to airway obstruction and
symptoms in persistent asthma. Objective We aimed to determine phenotypic associations …
symptoms in persistent asthma. Objective We aimed to determine phenotypic associations …
[HTML][HTML] Forced vital capacity and low frequency reactance area measurements are associated with asthma control and exacerbations
R Chan, B Lipworth - Lung, 2022 - Springer
Introduction Forced vital capacity (FVC) is often preserved in severe asthma unless there is
evidence of either airway remodelling or air trapping. Area under the reactance curve (AX) …
evidence of either airway remodelling or air trapping. Area under the reactance curve (AX) …
Repeatability of impulse oscillometry in patients with severe asthma
Repeatability of impulse oscillometry in severe asthma is unknown. This study reports on
medium term repeatability for IOS and proposes values for within subject biological …
medium term repeatability for IOS and proposes values for within subject biological …
[HTML][HTML] Impaired respiratory system resistance and reactance are associated with bronchial wall thickening in persistent asthma
R Chan, C Duraikannu, MJ Thouseef… - The Journal of Allergy and …, 2023 - Elsevier
Background A recent study demonstrated a significant correlation between bronchial biopsy
airway remodeling and quantitative computed tomography looking at bronchial wall …
airway remodeling and quantitative computed tomography looking at bronchial wall …