Lysine methylation of histones in vivo occurs in three states: mono-, di- and tri-methyl 1 .
Histone H3 has been found to be di-methylated at lysine 4 (K4) in active euchromatic regions …

Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …

In eukaryotic cells the histone methylase SUV39H1 and the methyl-lysine binding protein HP1
functionally interact to repress transcription at heterochromatic sites 1 . Lysine 9 of histone …

Remarkable progress has been made in defining a new understanding of the role of mRNA
translation and protein synthesis in human cancer. Translational control is a crucial …

With an estimate of 350 million people chronically infected with the hepatitis B virus (HBV)
worldwide, it is critically important to understand how persistent HBV infection is maintained …

Single-photon sources are basic building blocks for quantum communications, processing,
and metrology. Solid-state quantum emitters in semiconductors have the potential for robust …

… Robert Schneider was the head of a small county hospital in Grosshöchstetten. His isolation
… Robert Schneider published some forty scientific papers and in 1981 a much admired …

Gene regulation in eukaryotes requires the coordinate interaction of chromatin-modulating
proteins with specific transcription factors such as the androgen receptor 1 . Gene activation …

Radiotherapy is under investigation for its ability to enhance responses to immunotherapy.
However, the mechanisms by which radiation induces anti-tumour T cells remain unclear. We …

Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis 1 ,
2 , 3 . We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an …