Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through
human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the …

CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as
a target for cancer immunotherapy. However, anti-CD25 antibodies have displayed limited …

Tobacco smoking causes lung cancer 1 , 2 – 3 , a process that is driven by more than 60
carcinogens in cigarette smoke that directly damage and mutate DNA 4 , 5 . The profound …

ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive
patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma (ccRCC…

Rationale: Stem cell–based tracheal replacement represents an emerging therapeutic option
for patients with otherwise untreatable airway diseases including long-segment congenital …

Mammalian development, adult tissue homeostasis and the avoidance of severe diseases
including cancer require a properly orchestrated cell cycle, as well as error-free genome …

The molecular alterations that occur in cells before cancer is manifest are largely uncharted.
Lung carcinoma in situ (CIS) lesions are the pre-invasive precursor to squamous cell …

This study reveals the dynamics and drivers of APOBEC3 gene expression in preinvasive
disease and the exacerbation of cellular diversity by APOBEC3B through DNA replication …

Myofibroblasts are the key effector cells responsible for excessive extracellular matrix deposition
in multiple fibrotic conditions, including idiopathic pulmonary fibrosis (IPF). The PI3K/Akt/…

Epithelial organ remodeling is a major contributing factor to worldwide death and disease,
costing healthcare systems billions of dollars every year. Despite this, most fundamental …