Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): a randomised, double-blind, placebo-controlled, phase 3 trial

…, B Mayer, SW Yancey, AR Sousa, R Chan… - The Lancet …, 2021 - thelancet.com
Background Chronic rhinosinusitis with nasal polyps affects approximately 2–4% of the
general population, and long-term use of systemic corticosteroids is associated with adverse …

A computer study of finite-amplitude water waves

RKC Chan, RL Street - Journal of computational physics, 1970 - Elsevier
The nonlinear properties of finite-amplitude water waves are modelled by a numerical method
based on the Marker and Cell technique. The paper introduces the Stanford University …

A comparison of the incidence and location of positive surgical margins in robotic assisted laparoscopic radical prostatectomy and open retropubic radical …

JA Smith, RC Chan, SS Chang, SD Herrell… - The Journal of …, 2007 - auajournals.org
Purpose : Surgical technique, patient characteristics and method of pathological review may
influence surgical margin status. We evaluated the incidence and location of positive …

Results of Prevention of REStenosis with Tranilast and its Outcomes (PRESTO) trial

…, J Popma, SB King III, AM Lincoff, JE Tcheng, R Chan… - Circulation, 2002 - Am Heart Assoc
Background— Restenosis after percutaneous coronary intervention (PCI) is a major
problem affecting 15% to 30% of patients after stent placement. No oral agent has shown a …

Immunorestitution disease involving the innate and adaptive response

…, K Yuen, W Chan, ESK Ma, RMT Chan - Clinical Infectious …, 2000 - academic.oup.com
Immunorestitution disease (IRD) is defined as an acute symptomatic or paradoxical deterioration
of a (presumably) preexisting infection that is temporally related to the recovery of the …

Risk Factors for Acquisition of Levofloxacin-Resistant Streptococcus pneumoniae: A Case-Control Study

…, TK Ng, VCC Cheng, RMT Chan - Clinical infectious …, 2001 - academic.oup.com
A case-control study was conducted to identify the risk factors associated with levofloxacin-resistant
Streptococcus pneumoniae (LRSP) colonization or infection. Twenty-seven case …

The roles of eosinophils and interleukin‐5 in the pathophysiology of chronic rhinosinusitis with nasal polyps

…, PH Howarth, SW Yancey, R Chan… - International forum of …, 2022 - Wiley Online Library
… Yancey, and Robert Chan are employees of GSK and own stocks/shares; Claus Bachert
has participated in advisory boards and received speaker fees from Sanofi, Novartis, …

On explicit two-derivative Runge-Kutta methods

RPK Chan, AYJ Tsai - Numerical Algorithms, 2010 - Springer
The theory of Runge-Kutta methods for problems of the form y′ = f(y) is extended to include
the second derivative y′′ = g(y): = f′(y)f(y). We present an approach to the order …

[HTML][HTML] Kinetics of tumor destruction by chimeric antigen receptor-modified T cells

U Anurathapan, RC Chan, HF Hindi, R Mucharla… - Molecular Therapy, 2014 - cell.com
The use of chimeric antigen receptor (CAR)–modified T cells as a therapy for hematologic
malignancies and solid tumors is becoming more widespread. However, the infusion of a T-…

[HTML][HTML] Mepolizumab for chronic rhinosinusitis with nasal polyps: treatment efficacy by comorbidity and blood eosinophil count

…, O Kante, DE Karidi-Andrioti, B Mayer, RH Chan… - Journal of Allergy and …, 2022 - Elsevier
Background In the Phase III SYNAPSE study, mepolizumab reduced nasal polyp (NP) size
and nasal obstruction in chronic rhinosinusitis with NP (CRSwNP). Objective To assess the …