Redesigning nature's poisons to create anti-tumor reagents

ES Vitetta, RJ Fulton, RD May, M Till, JW Uhr - Science, 1987 - science.org
Immunotoxins are conjugates of cell-reactive antibodies and toxins or their subunits. In this
report, the chemistry, biology, pharmacokinetics, and anti-tumor effects of first generation …

Cancer Dormancy: Studies of the Murine BCL1 Lymphoma

JW Uhr, T Tucker, RD May, H Siu, ES Vietta - Cancer research, 1991 - AACR
Dormancy in the murine BCL 1 lymphoma can be induced by several strategies including
cytoreductive therapy of mice with large tumor burdens and challenge of allogeneic chimeric …

[HTML][HTML] Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

…, F Haman, EE Turcotte, D Richard… - The Journal of …, 2012 - Am Soc Clin Investig
… , which may render BAT adipocytes more prepared to clear circulating glucose and lipid. …
in the present study suggests that unknown factors may modulate BAT volume and thermogenic …

Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators

MAC Déry, MD Michaud, DE Richard - … journal of biochemistry & cell biology, 2005 - Elsevier
… 2 (MMP2), cathepsin D (CATHD), urokinase plasminogen activator receptor (UPAR), keratin
14/18/19 (KRT) can be modified by HIF-1 and may be implicated in migration of endothelial …

Content validity in psychological assessment: A functional approach to concepts and methods.

SN Haynes, D Richard, ES Kubany - Psychological assessment, 1995 - psycnet.apa.org
This article examines the definition, importance, conceptual basis, and functional nature of
content validity, with an emphasis on psychological assessment in clinical situations. The …

L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications

DM Richard, MA Dawes, CW Mathias… - International …, 2009 - journals.sagepub.com
An essential component of the human diet, L-tryptophan is critical in a number of metabolic
functions and has been widely used in numerous research and clinical trials. This review …

Nucleoside triphosphates are required to open the CFTR chloride channel

MP Anderson, HA Berger, DP Rich, RJ Gregory… - Cell, 1991 - cell.com
… considered the possibility that the CFfR NBDs may regulate the channel, rather than support
… The approach to this question is complicated because, as shown in Figure 1, ATP may be …

Emergence of genomic diversity and recurrent mutations in SARS-CoV-2

L Van Dorp, M Acman, D Richard, LP Shaw… - Infection, Genetics and …, 2020 - Elsevier
… in Orf1ab in the regions encoding Nsp6, Nsp11, Nsp13, and one in the Spike protein are
characterised by a particularly large number of recurrent mutations (>15 events) which may

Rapidly decaying supernova 2010X: a candidate “. Ia” explosion

…, I Arcavi, DA Howell, M Sullivan, DJ Rich… - The Astrophysical …, 2010 - iopscience.iop.org
… If aluminum is present, we speculate that this may be an accretion-induced collapse of an
O-Ne-Mg white dwarf. If helium is present, all observables of SN 2010X are consistent with …

Mutations in CFTR associated with mild-disease-form CI- channels with altered pore properties

DN Sheppard, DP Rich, LS Ostedgaard, RJ Gregory… - Nature, 1993 - nature.com
… This may explain the lower than expected frequency of this rearrangement. … machinery
may play some other unknown role in directing the production of the canonical rearrangements. …