Although multiple gene and protein expression have been extensively profiled in human
pulmonary arterial hypertension (PAH), the mechanism for the development and progression of …

Objectives: To study the impact of ex vivo lung perfusion (EVLP) on cytokines, chemokines,
and growth factors and their correlation with graft performance either during perfusion or after …

Background Ex vivo lung perfusion (EVLP) is being increasingly applied as a method to
evaluate and treat donor lungs for transplantation. However, with the previous limited worldwide …

A variety of airborne pathogens can induce inflammatory responses in airway epithelial cells,
which is a crucial component of host defence. However, excessive inflammatory responses …

Ischemia-reperfusion (I/R)-induced lung injury undermines lung transplantation (LTx) outcomes
by predisposing lung grafts to primary graft dysfunction (PGD). Necrosis is a feature of I/…

Introduction The ex vivo lung perfusion (EVLP) technique has been developed to assess
the function of marginal donor lungs and has significantly increased donor lung utilisation. …

Objectives Ex vivo lung perfusion provides an innovative method to assess and repair donor
lungs. The current Toronto ex vivo lung perfusion protocol can reliably and reproducibly …

We and others have demonstrated that acellular normothermic ex vivo lung perfusion of high‐risk
donor lungs can result in posttransplant outcomes equivalent to that of …

Background Normothermic ex vivo lung perfusion (EVLP) is a preservation technique that
allows reassessment of donor lungs before transplantation. We hypothesized that the …

Introduction Transplantation of lungs from donation after circulatory death (DCD) in addition
to donation after brain death (DBD) became routine worldwide to address the global organ …