Caspase-8 has two opposing biological functions—it promotes cell death by triggering the
extrinsic pathway of apoptosis, but also has a survival activity, as it is required for embryonic …

Receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis is thought to be the
pathophysiologically predominant pathway that leads to regulated necrosis of parenchymal …

In the early 2000s, receptor-interacting serine/threonine protein kinase 1 (RIPK1), a molecule
already recognized as an important regulator of cell survival, inflammation and disease, …

Pattern Recognition Receptors (PRRs) are proteins capable of recognizing molecules
frequently found in pathogens (the so-called Pathogen-Associated Molecular Patterns—PAMPs), …

Members of the nuclear factor-κB (NF-κB) family of transcriptional regulators are central
mediators of the cellular inflammatory response. Although constitutive NF-κB signalling is …

Regulated necrosis (RN) may result from cyclophilin (Cyp)D-mediated mitochondrial permeability
transition (MPT) and receptor-interacting protein kinase (RIPK)1-mediated necroptosis…

Receptor-interacting protein kinase (RIPK)-1 is involved in RIPK3-dependent and -independent
signaling pathways leading to cell death and/or inflammation. Genetic ablation of ripk1 …

The Nlrp3 inflammasome is critical for host immunity, but the mechanisms controlling its
activation are enigmatic. In this study, we show that loss of FADD or caspase-8 in a RIP3-…

Caspase-8, the initiator caspase of the death receptor pathway of apoptosis, its adapter
molecule, FADD, required for caspase-8 activation, and cFLIP L , a caspase-8-like protein that …

In vitro drug screening is widely used in the development of new drugs, because they constitute
a cost-effective approach to select compounds with more potential for therapy. They are …