In order to quantify small molecules at the early stage of drug discovery, we developed a
quantitation approach based on mass spectrometry imaging (MSI) using matrix-assisted laser …

We investigated in a rabbit model, the eye distribution of topically instilled benzalkonium_(BAK)
chloride a commonly used preservative in eye drops using mass spectrometry imaging. …

Generation of skin distribution profiles and reliable determination of drug molecule concentration
in the target region are crucial during the development process of topical products for …

Hepatocellular carcinoma is the most frequent primary liver cancer. Macroautophagy/autophagy
inhibitors have been extensively studied in cancer but, to date, none has reached …

Hyaluronic acid (HA) is a major component of the skin, contributing to tissue hydration and
biomechanical properties. As HA content in the skin decreases with age, formulas containing …

As tumors are very heterogeneous, investigating the penetration and concentration of an
anticancer drug in different histological regions of a tumor is key to evaluate the efficacy, to …

Previously, MS was often used to analyze the composition and structure of biological molecules
present in solutions. Today, technology developments enable the application of MS for …

Nanoparticles are widely used as carrier for the delivery of Active Principle Ingredients (API).
From safety point of view, the fate of nanoparticles and API after administration becomes a …

Simple Summary Primary cutaneous T-cell lymphomas (CTCLs) are a group of lymphomas
that present in the skin without extracutaneous localizations at diagnosis. Recent studies in …

Background Lactic acid is a common active ingredient in many topical skincare products;
however, measuring its delivery into the skin is challenging due to the presence of a large level …