Molecular and secretory profiles of human mesenchymal stromal cells and their abilities to maintain primitive hematopoietic progenitors

…, F Wein, A Diehlmann, M Frankhauser, R Schubert… - Stem …, 2007 - academic.oup.com
Mesenchymal stromal cells (MSC) provide a supportive cellular microenvironment and are
able to maintain the self-renewal capacity of hematopoietic progenitor cells (HPC). Isolation …

[HTML][HTML] Selective inhibition of tumor growth by clonal NK cells expressing an ErbB2/HER2-specific chimeric antigen receptor

…, H Holtgreve-Grez, A Jauch, M Schmidt, R Schubert… - Molecular therapy, 2015 - cell.com
Natural killer (NK) cells are an important effector cell type for adoptive cancer immunotherapy.
Similar to T cells, NK cells can be modified to express chimeric antigen receptors (CARs) …

Elevated oxidative stress in patients with ataxia telangiectasia

J Reichenbach, R Schubert, D Schindler… - … and redox signaling, 2002 - liebertpub.com
Ataxia telangiectasia (AT) is a pleiotropic genetic disorder characterized by progressive
neurodegeneration, especially of cerebellar Purkinje cells, immunodeficiency, increased …

Sputum biomarker profiles in cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) and association between pulmonary function

…, R Buhl, S Schmitt-Grohé, S Zielen, R Schubert - Cytokine, 2010 - Elsevier
Lung diseases like cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD)
are associated with chronic airway inflammation. The aim of our study was to compare a …

Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice

R Schubert, L Erker, C Barlow… - Human molecular …, 2004 - academic.oup.com
Reactive oxygen species (ROS) are important endogenous etiological agents for DNA
damage, and ROS perform critical signaling functions in apoptosis, stress responses and …

Comprehensive phenotypic characterization of human adipose-derived stromal/stem cells and their subsets by a high throughput technology

…, S Zielen, H Geiger, P Bader, R Schubert - Stem cells and …, 2013 - liebertpub.com
The characterization of adipose-derived stromal/stem cells (ASCs) remains difficult due to
the lack of a definitive and unique cellular marker. Therefore, a combination of markers is …

[HTML][HTML] Primary CD33-targeting CAR-NK cells for the treatment of acute myeloid leukemia

…, J Campe, K Stein, H Kreyenberg, R Schubert… - Blood cancer …, 2022 - nature.com
Acute myeloid leukemia (AML) is a malignant disorder derived from neoplastic myeloid
progenitor cells characterized by abnormal proliferation and differentiation. Although novel …

[HTML][HTML] The German national registry of primary immunodeficiencies (2012–2017)

…, S Bakhtiar, JY Lee, U Heß, R Schubert… - Frontiers in …, 2019 - frontiersin.org
Introduction: The German PID-NET registry was founded in 2009, serving as the first national
registry of patients with primary immunodeficiencies (PID) in Germany. It is part of the …

Comparison of cytokine levels from undiluted vitreous of untreated patients with retinal vein occlusion

…, M Michaelis, J Cinatl, R Schubert… - Acta …, 2012 - Wiley Online Library
Purpose: To compare cytokines in undiluted vitreous of treatment‐naïve patients with macular
oedema without vitreomacular traction secondary to branch (BRVO), central (CRVO) and …

Human adipose-derived mesenchymal stem cells in vitro: evaluation of an optimal expansion medium preserving stemness

PC Baer, N Griesche, W Luttmann, R Schubert… - Cytotherapy, 2010 - Elsevier
Background aims The potential of cultured adipose-derived stem cells (ASC) in
regenerative medicine and new cell therapeutic concepts has been shown recently by many …