… to rats with an experimental protocol identical to that used for SU5416, confirmed our results
of increased lung mean linear intercept as observed in rats treated with SU5416 (RM Tuder, …

… In contrast, the growth of rat aorta smooth muscle cells maintained in low serum in vitro was
not affected by SU5416 (RM Tuder, unpublished observations). Remarkably, we did not find …

The plexiform lesion in primary pulmonary hypertension is a glomeruloid structure forming
channels in branches of the pulmonary artery. These lesions have been considered an …

Although inflammation and protease/antiprotease imbalance have been postulated to be
critical in cigarette smoke–induced (CS-induced) emphysema, oxidative stress has been …

Prostacyclin is a powerful vasodilator and inhibits platelet adhesion and cell growth. We
hypothesized that a decrease in expression of the critical enzyme PGI 2 synthase (PGI 2 -S) in …

occur in patients with idiopathic PPH. 6, 7 Whether these cells are derived from the endothelial
progenitor cells obtained from the mobilization of bone marrow by growth factors such as …

Pulmonary arterial hypertension (PAH) includes various forms of pulmonary hypertension of
different etiology but similar clinical presentation and functional derangement. …

Emphysema due to cigarette smoking is characterized by a loss of alveolar structures. We
hypothesize that the disappearance of alveoli involves apoptosis of septal endothelial cells …

Idiopathic interstitial pneumonias (IIPs) have a progressive and often fatal course, and their
enigmatic etiology has complicated approaches to effective therapies. Idiopathic pulmonary …

Sepsis, a systemic inflammatory response to infection, commonly progresses to acute lung
injury (ALI), an inflammatory lung disease with high morbidity. We postulated that sepsis-…