Fentanyl is a synthetic opioid agonist which interacts primarily with the μ-opioid receptor.
The low molecular weight, high potency and lipid solubility of fentanyl make it suitable for …

The free radical nitric oxide (NO) is an important mediator of many biological processes.
Interestingly, the molecule appears to be a two-edged sword. Apart from NO having a function …

The discovery that nitric oxide (NO) reacts with Superoxide (O 2 − ) forming peroxynitrite (ONOO
− ) (1) and the proof that this reaction occurs in vivo (2,3) holds enormous implications …

Peroxynitrite (ONOO − ) the highly reactive coupling product of nitric oxide and superoxide,
has been implicated in the pathogenesis of an increasing number of (inflammatory) diseases. …

Sertraline is a selective serotonin reuptake inhibitor (SSRI) with well established antidepressant
and anxiolytic activity. Results from several well designed trials show that sertraline (50 …

▴ Voriconazole, a broad-spectrum triazole antifungal agent, inhibits the cytochrome P450-dependent
enzyme 14-α-sterol demethylase, thereby disrupting the fungal membrane and …

Montelukast is a cysteinyl leukotriene receptor antagonist which is used as a preventive
treatment for persistent asthma in patients ≥2 years of age. In children aged 6 to 14 years …

▴ Moxifloxacin is a fluoroquinolone antibacterial agent which attains good penetration into
peripheral tissues and inflammatory fluids. The drug shows good in vitro activity against …

The aminosalicylate balsalazide is a prodrug which is metabolised by bacterial azo reductases
in the colon to release its therapeutically active moiety mesalazine [mesalamine (US) or 5…

Presents evidence in the production of peroxynitrite in the respiratory tract and its possible
role in the oxidative damage in the lung. Implications of peroxynitrite in airway …