Pharmacological treatment of idiopathic pulmonary fibrosis–preclinical and clinical studies of pirfenidone, nintedanib, and N-acetylcysteine
M Myllärniemi, R Kaarteenaho - European clinical respiratory …, 2015 - Taylor & Francis
Three recent clinical trials on the pharmacologic treatment of idiopathic pulmonary fibrosis (IPF)
mark a new chapter in the management of patients suffering from this very severe fibrotic …
mark a new chapter in the management of patients suffering from this very severe fibrotic …
[HTML][HTML] The current position of surgical lung biopsy in the diagnosis of idiopathic pulmonary fibrosis
R Kaarteenaho - Respiratory research, 2013 - Springer
A new international statement defines usual interstitial pneumonia (UIP) which is a histological
and radiological form of idiopathic pulmonary fibrosis (IPF) more precisely than previously…
and radiological form of idiopathic pulmonary fibrosis (IPF) more precisely than previously…
[HTML][HTML] Idiopathic pulmonary fibrosis-a systematic review on methodology for the collection of epidemiological data
…, ER Salomaa, U Hodgson, R Kaarteenaho… - BMC pulmonary …, 2013 - Springer
Background Recent studies suggest that the incidence of idiopathic pulmonary fibrosis (IPF)
is rising. Accurate epidemiological data on IPF, however, are sparse and the results of …
is rising. Accurate epidemiological data on IPF, however, are sparse and the results of …
[HTML][HTML] Pirfenidone and nintedanib modulate properties of fibroblasts and myofibroblasts in idiopathic pulmonary fibrosis
…, S Korpela, U Zagai, MC Sköld, R Kaarteenaho - Respiratory …, 2016 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is an incurable lung disease with a poor
prognosis. Fibroblasts and myofibroblasts are the key cells in the fibrotic process. Recently two …
prognosis. Fibroblasts and myofibroblasts are the key cells in the fibrotic process. Recently two …
Cadherin-11–mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-β
…, P Pakshir, B Wu, S Boo, M Kiebalo, R Kaarteenaho… - Science …, 2019 - science.org
Macrophages contribute to the activation of fibroblastic cells into myofibroblasts, which
secrete collagen and contract the collagen matrix to acutely repair injured tissue. Persistent …
secrete collagen and contract the collagen matrix to acutely repair injured tissue. Persistent …
Demographics and survival of patients with idiopathic pulmonary fibrosis in the FinnishIPF registry
…, ER Salomaa, U Hodgson, R Kaarteenaho… - ERJ open …, 2019 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is characterised by unpredictable disease course and poor
survival. After the introduction of novel antifibrotic drugs, the prognosis of patients with IPF …
survival. After the introduction of novel antifibrotic drugs, the prognosis of patients with IPF …
Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD
…, H Merikallio, R Kaarteenaho… - European …, 2016 - Eur Respiratory Soc
… (r=0.87; p=0.0009) and mRNA levels of enzymes putatively involved in their biosynthesis
(r=0.96; p=0.003). Leukotoxin levels correlated with goblet cell abundance (r=0.72; p=0.028). …
(r=0.96; p=0.003). Leukotoxin levels correlated with goblet cell abundance (r=0.72; p=0.028). …
[HTML][HTML] Variable course of disease of rheumatoid arthritis-associated usual interstitial pneumonia compared to other subtypes
…, HP Kettunen, TA Selander, RL Kaarteenaho - BMC pulmonary …, 2016 - Springer
Background In rheumatoid arthritis-associated interstitial lung disease (RA-ILD), occurring
in 10 % of patients with patients with RA, usual interstitial pattern (UIP) has shown to …
in 10 % of patients with patients with RA, usual interstitial pattern (UIP) has shown to …
[PDF][PDF] Leveraging global multi-ancestry meta-analysis in the study of idiopathic pulmonary fibrosis genetics
The research of rare and devastating orphan diseases, such as idiopathic pulmonary
fibrosis (IPF) has been limited by the rarity of the disease itself. The prognosis is poor—the …
fibrosis (IPF) has been limited by the rarity of the disease itself. The prognosis is poor—the …
[HTML][HTML] Several high-resolution computed tomography findings associate with survival and clinical features in rheumatoid arthritis-associated interstitial lung disease
…, MS Kärkkäinen, TA Selander, RL Kaarteenaho - Respiratory …, 2018 - Elsevier
… (GGO) and the duration of RA (r = −0.308, p = 0.023). The extents of honeycombing (r =
0.266, p = 0.046), traction bronchiectasis (r = 0.333, p = 0.012) and architectural distortion (…
0.266, p = 0.046), traction bronchiectasis (r = 0.333, p = 0.012) and architectural distortion (…