Selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed
antidepressant class today and exert their antidepressant-like effects by increasing synaptic …

Tract-tracing and electrophysiology studies have revealed that major inputs to the nucleus
locus coeruleus (LC) are found in two structures, the nucleus paragigantocellularis (PGi) and …

Stress is associated with the onset and severity of several psychiatric disorders that occur
more frequently in women than men, including posttraumatic stress disorder (PTSD) and …

Ibrutinib, a first-in-class once-daily oral Bruton tyrosine kinase inhibitor indicated for chronic
lymphocytic leukemia (CLL), is continued until progressive disease or unacceptable toxicity. …

Background Avoiding intubation is a major goal in the management of respiratory failure,
particularly in immunosuppressed patients. Nevertheless, there are only limited data on the …

The sodium retention associated with liquorice ingestion has been thought to be due to a
direct mineralocorticoid effect, despite the fact that it does not seem to occur in patients or …

Corticotropin-releasing factor (CRF) administered intraventricularly (0.5 nmol) was found to
increase the discharge rates of locus coeruleus (LC) neurons in anesthetized rats. A similar …

Although hypothalamic–pituitary–adrenal axis activation is generally considered to be the
hallmark of the stress response, many of the same stimuli that initiate this response also …

Ibrutinib, a Bruton tyrosine kinase inhibitor, is approved for treatment of various B‐cell
malignancies. In ibrutinib clinical studies, low‐grade haemorrhage was common, whereas major …

Interoception refers to the representation of the internal states of an organism, and includes
the processes by which it senses, interprets, integrates, and regulates signals from within …