Objectives Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is
characterised by neutrophil activation. An elevated prevalence of venous thromboembolic events …

The interaction of transcription factors is critical in the regulation of gene expression. This
study characterized the mechanism by which NF-κB family members interact to regulate the …

Objective Toll‐like receptors (TLRs) are pattern‐associated receptors in innate immunity
that may be involved in the recognition of self antigens and the production of pathogenic …

Introduction Prevalence of insulin resistance and the metabolic syndrome has been
reported to be high in rheumatoid arthritis (RA) patients. Tumor necrosis factor (TNF), a pro-…

Objectives: Patients with rheumatoid arthritis have an increased risk for cardiovascular disease
(CVD). The prevalence of metabolic syndrome (MetS)—a major contributor to CVD—in a …

Objective T cells play a major role in the pathogenesis of rheumatoid arthritis (RA). The
programmed death 1 (PD‐1)/programmed death ligand 1 (PDL‐1) pathway is involved in …

Objective The first 3 months after symptom onset represent an important therapeutic window
for rheumatoid arthritis (RA). This study investigates the extent and causes of delay in …

Objective: Bone marrow (BM) mesenchymal stem cells (MSCs) are being considered as
potential therapeutic agents in various inflammatory autoimmune diseases for their tissue-repair …

Introduction Interleukin-1β (IL-1β) is a major inflammatory cytokine, produced predominantly
by innate immune cells through NLRP3-inflammasome activation. Both intrinsic and …

Subjects with metabolic syndrome–a constellation of cardiovascular risk factors of which
central obesity and insulin resistance are the most characteristic–are at increased risk for …