[PDF][PDF] Activated PMN exosomes: pathogenic entities causing matrix destruction and disease in the lung

KR Genschmer, DW Russell, C Lal, T Szul, PE Bratcher… - Cell, 2019 - cell.com
Here, we describe a novel pathogenic entity, the activated PMN (polymorphonuclear leukocyte,
ie, neutrophil)-derived exosome. These CD63 + /CD66b + nanovesicles acquire surface-…

[HTML][HTML] Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium

…, MT Montgomery, JL Everman, PE Bratcher… - Nature …, 2020 - nature.com
Cigarette smoke first interacts with the lung through the cellularly diverse airway epithelium
and goes on to drive development of most chronic lung diseases. Here, through single cell …

The role of matrix metalloproteinases in cystic fibrosis lung disease

A Gaggar, A Hector, PE Bratcher… - European …, 2011 - Eur Respiratory Soc
Significant airway remodelling is a major component of the increased morbidity and
mortality observed in cystic fibrosis (CF) patients. These airways feature ongoing leukocytic …

[HTML][HTML] Elexacaftor is a CFTR potentiator and acts synergistically with ivacaftor during acute and chronic treatment

CA Shaughnessy, PL Zeitlin, PE Bratcher - Scientific reports, 2021 - nature.com
Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance
regulator (CFTR), which lead to early death due to progressive lung disease. The …

Identification of natural pneumococcal isolates expressing serotype 6D by genetic, biochemical and serological characterization

PE Bratcher, KH Kim, JH Kang, JY Hong… - …, 2010 - microbiologyresearch.org
The recently discovered pneumococcal serotype 6C was created when the original wciN gene
in the 6A capsule gene locus was naturally replaced with a new gene. Since the capsule …

Toll-like receptor 4 engagement mediates prolyl endopeptidase release from airway epithelia via exosomes

T Szul, PE Bratcher, KB Fraser, M Kong… - American journal of …, 2016 - atsjournals.org
Proteases are important regulators of pulmonary remodeling and airway inflammation. Recently,
we have characterized the enzyme prolyl endopeptidase (PE), a serine peptidase, as a …

[HTML][HTML] Impact of azithromycin on the clinical and antimicrobial effectiveness of tobramycin in the treatment of cystic fibrosis

DP Nichols, CL Happoldt, PE Bratcher… - Journal of Cystic …, 2017 - Elsevier
Background Concomitant use of oral azithromycin and inhaled tobramycin occurs in approximately
half of US cystic fibrosis (CF) patients. Recent data suggest that this combination may …

[HTML][HTML] Alterations in blood leukocytes of G551D-bearing cystic fibrosis patients undergoing treatment with ivacaftor

PE Bratcher, SM Rowe, G Reeves, T Roberts… - Journal of Cystic …, 2016 - Elsevier
Background Ivacaftor improves clinical outcome by potentiation of mutant G551D CFTR.
Due to the presence of CFTR in monocytes and polymorphonuclear neutrophils (PMNs), we …

Doxycycline improves clinical outcomes during cystic fibrosis exacerbations

X Xu, T Abdalla, PE Bratcher… - European …, 2017 - Eur Respiratory Soc
Matrix metalloprotease-9 (MMP-9) plays a role in progression of cystic fibrosis, and
doxycycline can reduce MMP-9 in vitro. Here, we explore the effect of doxycycline during cystic …

HuR promotes the molecular signature and phenotype of activated microglia: Implications for amyotrophic lateral sclerosis and other neurodegenerative diseases

…, Y Si, S Kim, W Luo, DK Crossman, PE Bratcher… - Glia, 2017 - Wiley Online Library
In neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), chronic activation
of microglia contributes to disease progression. Activated microglia produce cytokines, …