User profiles for Polina L Yarova
Polina YarovaNewcastle University Verified email at bath.edu Cited by 780 |
Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma
Airway hyperresponsiveness and inflammation are fundamental hallmarks of allergic asthma
that are accompanied by increases in certain polycations, such as eosinophil cationic …
that are accompanied by increases in certain polycations, such as eosinophil cationic …
The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure
M Schepelmann, PL Yarova… - … of Physiology-Cell …, 2016 - journals.physiology.org
The extracellular calcium-sensing receptor CaSR is expressed in blood vessels where its
role is not completely understood. In this study, we tested the hypothesis that the CaSR …
role is not completely understood. In this study, we tested the hypothesis that the CaSR …
Improving and accelerating the differentiation and functional maturation of human stem cell‐derived neurons: role of extracellular calcium and GABA
PJ Kemp, DJ Rushton, PL Yarova… - The Journal of …, 2016 - Wiley Online Library
Neurons differentiated from pluripotent stem cells using established neural culture conditions
often exhibit functional deficits. Recently, we have developed enhanced media which both …
often exhibit functional deficits. Recently, we have developed enhanced media which both …
Smooth Muscle Ca2+‐Activated and Voltage‐Gated K+ Channels Modulate Conducted Dilation in Rat Isolated Small Mesenteric Arteries
Please cite this paper as: Beleznai, Yarova, Yuill and Dora (2011). Smooth Muscle Ca 2+ ‐Activated
and Voltage‐Gated K + Channels Modulate Conducted Dilation in Rat Isolated …
and Voltage‐Gated K + Channels Modulate Conducted Dilation in Rat Isolated …
The calcium‐sensing receptor: one of a kind
…, SC Brennan, PL Yarova… - Experimental …, 2015 - Wiley Online Library
Daniela Riccardi has always been fascinated with how cells sense changes in their environment
and their responses at the molecular and cellular through to whole-organism level. The …
and their responses at the molecular and cellular through to whole-organism level. The …
Vascular hyperpolarization to β‐adrenoceptor agonists evokes spreading dilatation in rat isolated mesenteric arteries
CJ Garland, PL Yarova… - British journal of …, 2011 - Wiley Online Library
BACKGROUND AND PURPOSE β‐Adrenoceptor stimulation causes pronounced vasodilatation
associated with smooth muscle hyperpolarization. Although the hyperpolarization is …
associated with smooth muscle hyperpolarization. Although the hyperpolarization is …
Topical therapy with negative allosteric modulators of the calcium-sensing receptor (calcilytics) for the management of asthma: the beginning of a new era?
In this review article we present the evidence to date supporting the role of the calcium-sensing
receptor (CaSR) as a key, pluripotential molecular trigger for asthma and speculate on …
receptor (CaSR) as a key, pluripotential molecular trigger for asthma and speculate on …
Characterization of negative allosteric modulators of the calcium-sensing receptor for repurposing as a treatment of asthma
PL Yarova, P Huang, MW Schepelmann, R Bruce… - … of Pharmacology and …, 2021 - ASPET
Asthma is still an incurable disease, and there is a recognized need for novel small-molecule
therapies for people with asthma, especially those poorly controlled by current treatments. …
therapies for people with asthma, especially those poorly controlled by current treatments. …
An atomic force microscope nanoscalpel for nanolithography and biological applications
…, AV Moskalenko, O Dudko, PL Yarova… - …, 2009 - iopscience.iop.org
We present the fabrication of specialized nanotools, termed nanoscalpels, and their application
for nanolithography and nanomechanical manipulation of biological objects. Fabricated …
for nanolithography and nanomechanical manipulation of biological objects. Fabricated …
Impaired mineral ion metabolism in a mouse model of targeted calcium-sensing receptor (CaSR) deletion from vascular smooth muscle cells
…, TS Webberley, SC Brennan, PL Yarova… - Journal of the …, 2022 - journals.lww.com
Background Impaired mineral ion metabolism is a hallmark of CKD–metabolic bone disorder.
It can lead to pathologic vascular calcification and is associated with an increased risk of …
It can lead to pathologic vascular calcification and is associated with an increased risk of …