[HTML][HTML] Genome reduction and potential metabolic complementation of the dual endosymbionts in the whitefly Bemisia tabaci
Background The whitefly Bemisia tabaci is an important agricultural pest with global
distribution. This phloem-sap feeder harbors a primary symbiont, “Candidatus Portiera …
distribution. This phloem-sap feeder harbors a primary symbiont, “Candidatus Portiera …
Whole genome paired-end sequencing elucidates functional and phenotypic consequences of balanced chromosomal rearrangement in patients with developmental …
…, F Diguet, N Chatron, PA Rollat-Farnier… - Journal of medical …, 2019 - jmg.bmj.com
Background Balanced chromosomal rearrangements associated with abnormal phenotype
are rare events, but may be challenging for genetic counselling, since molecular …
are rare events, but may be challenging for genetic counselling, since molecular …
The Genome of Cardinium cBtQ1 Provides Insights into Genome Reduction, Symbiont Motility, and Its Settlement in Bemisia tabaci
D Santos-Garcia, PA Rollat-Farnier… - Genome Biology and …, 2014 - academic.oup.com
Many insects harbor inherited bacterial endosymbionts. Although some of them are not strictly
essential and are considered facultative, they can be a key to host survival under specific …
essential and are considered facultative, they can be a key to host survival under specific …
Contribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts
…, T Simonet, C Bardel, PA Rollat-Farnier… - The Lancet …, 2020 - thelancet.com
Background Systemic lupus erythematosus (SLE) is a rare immunological disorder and genetic
factors are considered important in its causation. Monogenic lupus has been associated …
factors are considered important in its causation. Monogenic lupus has been associated …
Exome sequencing and pathogenicity-network analysis of five French families implicate mTOR signalling and autophagy in familial sarcoidosis
…, V Besnard, PA Rollat-Farnier… - European …, 2019 - Eur Respiratory Soc
Sarcoidosis is a complex disease characterised by the presence of epithelioid non-caseating
granulomatous inflammation affecting multiple organs and whose aetiology has been …
granulomatous inflammation affecting multiple organs and whose aetiology has been …
Phenotypic differences between polygenic and monogenic hypobetalipoproteinemia
…, E Genin, R Redon, PA Rollat-Farnier… - … and Vascular Biology, 2021 - Am Heart Assoc
Objective: Primary hypobetalipoproteinemia is characterized by LDL-C (low-density lipoprotein
cholesterol) concentrations below the fifth percentile. Primary hypobetalipoproteinemia …
cholesterol) concentrations below the fifth percentile. Primary hypobetalipoproteinemia …
A new 165-SNP low-density lipoprotein cholesterol polygenic risk score based on next generation sequencing outperforms previously published scores in routine …
…, C Bardel, A Rimbert, P Moulin, PA Rollat-Farnier… - Translational …, 2023 - Elsevier
Genetic diagnosis of familial hypercholesterolemia (FH) remains unexplained in 30 to 70%
of patients after exclusion of monogenic disease. There is now a growing evidence that a …
of patients after exclusion of monogenic disease. There is now a growing evidence that a …
Development of a new expanded next‐generation sequencing panel for genetic diseases involved in dyslipidemia
O Marmontel, PA Rollat‐Farnier, AS Wozny… - Clinical …, 2020 - Wiley Online Library
The aim of this study was to provide an efficient tool: reliable, able to increase the molecular
diagnosis performance, to facilitate the detection of copy number variants (CNV), to assess …
diagnosis performance, to facilitate the detection of copy number variants (CNV), to assess …
Whole MYBPC3 NGS sequencing as a molecular strategy to improve the efficiency of molecular diagnosis of patients with hypertrophic cardiomyopathy
A Janin, V Chanavat, PA Rollat‐Farnier… - Human …, 2020 - Wiley Online Library
Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiomyopathy, historically
believed to affect 1 of 500 people. MYBPC3 pathogenic variations are the most frequent …
believed to affect 1 of 500 people. MYBPC3 pathogenic variations are the most frequent …
[HTML][HTML] Whole exome sequencing in three families segregating a pediatric case of sarcoidosis
A Calender, PA Rollat Farnier, A Buisson… - BMC medical …, 2018 - Springer
Background Sarcoidosis (OMIM 181000) is a multi-systemic granulomatous disorder of
unknown origin. Despite multiple genome-wide association (GWAS) studies, no major …
unknown origin. Despite multiple genome-wide association (GWAS) studies, no major …