Background Previous trials have shown that among high-risk patients with aortic stenosis,
survival rates are similar with transcatheter aortic-valve replacement (TAVR) and surgical …

Background Among patients with aortic stenosis who are at intermediate or high risk for
death with surgery, major outcomes are similar with transcatheter aortic-valve replacement (…

Aims The Valve Academic Research Consortium (VARC), founded in 2010, was intended to
(i) identify appropriate clinical endpoints and (ii) standardize definitions of these endpoints …

Background Transcatheter aortic valve replacement (TAVR) with the SAPIEN 3 valve
demonstrates good 30 day clinical outcomes in patients with severe aortic stenosis who are at …

Calcific aortic stenosis (AS) is the most prevalent heart valve disorder in developed countries.
It is characterized by progressive fibro-calcific remodelling and thickening of the aortic …

Low-flow, low-gradient (LF-LG) aortic stenosis (AS) may occur with depressed or preserved
left ventricular ejection fraction (LVEF), and both situations are among the most challenging …

Paradoxical low flow, low gradient, severe aortic stenosis (AS) despite preserved ejection
fraction is a recently described clinical entity whereby patients with severe AS on the basis of …

Background—Fluid energy loss across stenotic aortic valves is influenced by factors other
than the valve effective orifice area (EOA). We propose a new index that will provide a more …

An important proportion of patients with aortic stenosis (AS) have a ‘low-gradient’ AS, ie a
small aortic valve area (AVA <1.0 cm 2 ) consistent with severe AS but a low mean …

Aortic stenosis (AS) is one of the most common valvular diseases encountered in clinical
practice. Current guidelines recommend aortic valve replacement (AVR) when the aortic valve …