Background In two of three phase 3 trials, pirfenidone, an oral antifibrotic therapy, reduced
disease progression, as measured by the decline in forced vital capacity (FVC) or vital …

Background Nintedanib (formerly known as BIBF 1120) is an intracellular inhibitor that
targets multiple tyrosine kinases. A phase 2 trial suggested that treatment with 150 mg of …

Background Idiopathic pulmonary fibrosis is a progressive and fatal lung disease with inevitable
loss of lung function. The CAPACITY programme (studies 004 and 006) was designed …

Mechanisms that regulate inflammation and repair after acute lung injury are incompletely
understood. The extracellular matrix glycosaminoglycan hyaluronan is produced after tissue …

Gas exchange in the lung occurs within alveoli, air-filled sacs composed of type 2 and type
1 epithelial cells (AEC2s and AEC1s), capillaries, and various resident mesenchymal cells. …

In 1979, hyaluronan was demonstrated to bind specifically and with high affinity to intact cells
(1), and in 1980, it was shown to enhance cell motility on two-dimensional culture surfaces …

Background Idiopathic pulmonary fibrosis is a progressive lung disease with a high mortality
rate. Because the signaling pathways activated by several tyrosine kinase receptors have …

Despite the considerable progress in the classification of the idiopathic interstitial pneumonias
(IIPs), the lack of an international standard has resulted in variable and confusing …

Accumulation and turnover of extracellular matrix components are the hallmarks of tissue
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety of …

A hallmark of tissue injury and repair is the turnover of extracellular matrix components. This
review focuses on the role of the glycosaminoglycan hyaluronan in tissue injury and repair. …