Effects of hypervolemia on interdialytic hemodynamics and blood pressure control in hemodialysis patients

…, F de Heer, LMAB van Bortel, PMH Schiffers… - American journal of …, 1997 - Elsevier
The influence of hypervolemia on hemodynamics and interdialytic blood pressure, as well as
in relation to vascular compliance, was investigated in 10 hemodialysis patients who were …

Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats

LJ Schurgers, HMH Spronk, BAM Soute, PM Schiffers… - Blood, 2007 - ashpublications.org
Arterial calcification (AC) is generally regarded as an independent risk factor for cardiovascular
morbidity and mortality. Matrix Gla protein (MGP) is a potent inhibitor of AC, and its …

[HTML][HTML] The NOX toolbox: validating the role of NADPH oxidases in physiology and disease

…, P Scheurer, JJ Rob Hermans, P Schiffers… - Cellular and Molecular …, 2012 - Springer
Reactive oxygen species (ROS) are cellular signals but also disease triggers; their relative
excess (oxidative stress) or shortage (reductive stress) compared to reducing equivalents are …

[HTML][HTML] Placental mitochondrial abnormalities in preeclampsia

…, PA Leermakers, CBM Tulen, PMH Schiffers… - Reproductive …, 2021 - Springer
Preeclampsia complicates 5–8% of all pregnancies worldwide, and although its pathophysiology
remains obscure, placental oxidative stress and mitochondrial abnormalities are …

Chymase: a multifunctional player in pulmonary hypertension associated with lung fibrosis

…, JGR De Mey, G Fazzi, P Schiffers… - European …, 2015 - Eur Respiratory Soc
Limited literature sources implicate mast-cell mediator chymase in the pathologies of pulmonary
hypertension and pulmonary fibrosis. However, there is no evidence on the contribution …

Imaging collagen in intact viable healthy and atherosclerotic arteries using fluorescently labeled CNA35 and two-photon laser scanning microscopy

…, MJE Kuijpers, PHM Schiffers… - Molecular …, 2007 - journals.sagepub.com
We evaluated CNA35 as a collagen marker in healthy and atherosclerotic arteries of mice
after both ex vivo and in vivo administration and as a molecular imaging agent for the …

[HTML][HTML] NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype

…, A Teubner, PH Huang, CY Hsu, PMH Schiffers… - PLoS …, 2020 - journals.plos.org
Hypertension is the most important cause of death and disability in the elderly. In 9 out of 10
cases, the molecular cause, however, is unknown. One mechanistic hypothesis involves …

[HTML][HTML] Hypoxia-induced mitochondrial abnormalities in cells of the placenta

…, I Kaminski, I Geomini, T Lemmens, PMH Schiffers… - PloS one, 2021 - journals.plos.org
Introduction Impaired utero-placental perfusion is a well-known feature of early preeclampsia
and is associated with placental hypoxia and oxidative stress. Although aberrations at the …

Rutin protects against H2O2-triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in Human Umbilical Vein Endothelial Cells …

MM Sthijns, PM Schiffers, GM Janssen… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Background Rutin intake is associated with a reduced risk of cardiovascular disease (CVD).
The exact mechanism by which rutin can protect against CVD development is still enigmatic. …

Toward functional genomics of flow-induced outward remodeling of resistance arteries

JGR De Mey, PM Schiffers… - American Journal …, 2005 - journals.physiology.org
In resistance-sized arteries, a chronic increase in blood flow leads to increases in arterial
structural luminal diameter and arterial wall mass. In this review, we summarize recent …