User profiles for Paul S. Foster
Paul FosterUniversity of Newcastle Verified email at newcastle.edu.au Cited by 31316 |
Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.
Airways inflammation is thought to play a central role in the pathogenesis of asthma. However,
the precise role that individual inflammatory cells and mediators play in the development …
the precise role that individual inflammatory cells and mediators play in the development …
Eosinophils: biological properties and role in health and disease
Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation
of diverse inflammatory responses, as well as modulators of innate and adaptive immunity. In …
of diverse inflammatory responses, as well as modulators of innate and adaptive immunity. In …
[HTML][HTML] Eosinophils: changing perspectives in health and disease
HF Rosenberg, KD Dyer, PS Foster - Nature Reviews Immunology, 2013 - nature.com
Eosinophils have been traditionally perceived as terminally differentiated cytotoxic effector
cells. Recent studies have profoundly altered this simplistic view of eosinophils and their …
cells. Recent studies have profoundly altered this simplistic view of eosinophils and their …
[HTML][HTML] Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis
…, DP Witte, AA Pegg, PS Foster… - The Journal of …, 2003 - Am Soc Clin Investig
Asthma is on the rise despite intense, ongoing research underscoring the need for new
scientific inquiry. In an effort to provide unbiased insight into disease pathogenesis, we took an …
scientific inquiry. In an effort to provide unbiased insight into disease pathogenesis, we took an …
Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease
Allergic asthma is an inflammatory disease of the lung characterized by abnormal T helper-2
(T H 2) lymphocyte responses to inhaled antigens. The molecular mechanisms leading to …
(T H 2) lymphocyte responses to inhaled antigens. The molecular mechanisms leading to …
Eosinophil trafficking in allergy and asthma
Blood eosinophilia and tissue eosinophilia are characteristic features of allergic inflammation
and asthma, conditions associated with prominent production of T H 2 cytokines IL-4, IL-5, …
and asthma, conditions associated with prominent production of T H 2 cytokines IL-4, IL-5, …
An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to …
BACKGROUND Existing murine models of asthma lack many of the inflammatory and epithelial
changes that are typical of the human disease. Moreover, these models are frequently …
changes that are typical of the human disease. Moreover, these models are frequently …
[HTML][HTML] Fundamental signals that regulate eosinophil homing to the gastrointestinal tract
The histological identification of increased eosinophils in the gastrointestinal tract occurs in
numerous clinical disorders; however, there is a limited understanding of the mechanisms …
numerous clinical disorders; however, there is a limited understanding of the mechanisms …
Chemokines in asthma: cooperative interaction between chemokines and IL-13
…, N Zimmermann, GK Hershey, PS Foster… - Journal of Allergy and …, 2003 - Elsevier
The asthmatic response is characterized by elevated production of IgE, cytokines,
chemokines, mucus hypersecretion, airway obstruction, eosinophilia, and enhanced airway …
chemokines, mucus hypersecretion, airway obstruction, eosinophilia, and enhanced airway …
IL-13 induces eosinophil recruitment into the lung by an IL-5–and eotaxin-dependent mechanism
…, N Zimmermann, KI Matthaei, PS Foster… - Journal of Allergy and …, 2001 - Elsevier
Background: IL-13 induces several characteristic features of asthma, including airway
eosinophilia, airway hyperresponsiveness, and mucus overproduction; however, the mechanisms …
eosinophilia, airway hyperresponsiveness, and mucus overproduction; however, the mechanisms …