Aminoglycosides are highly potent, broad-spectrum antibiotics with many desirable
properties for the treatment of lifethreatening infections (28). Their history begins in 1944 with …

Aminoglycosides have long been one of the commonest causes of drug-induced nephrotoxicity
(137). Although a clear recognition of the patient-and treatment-related risk factors (91), …

The development and spread of antibiotic resistance in bacteria is a universal threat to both
humans and animals that is generally not preventable but can nevertheless be controlled, …

Pseudomonas aeruginosa is a major cause of nosocomial infections. This organism shows
a remarkable capacity to resist antibiotics, either intrinsically (because of constitutive …

Active efflux from procaryotic as well as eucaryotic cells strongly modulates the activity of a
large number of antibiotics. Effective antibiotic transport has now been observed for many …

Quinolones are one of the largest classes of antimicrobial agents used worldwide. This
review considers the quinolones that are available currently and used widely in Europe (…

OBJECTIVES: To evaluate the effect of pharmaceutical care provided in addition to acute
Geriatric Evaluation and Management (GEM) care on the appropriateness of prescribing. …

Over the last decades, numerous papers have appeared—and still are appearing—that
describe concentrations in tissues in an effort to predict the efficacy of an antimicrobial agent …

Intracellular penetration, accumulation and disposition are important parameters governing
the activity of antibiotics against intracellular bacteria. Beta-lactams diffuse into but do not …

The pharmacodynamic properties governing the activities of antibiotics against intracellular
Staphylococcus aureus are still largely undetermined. Sixteen antibiotics of seven different …