User profiles for Paul J.C. Hughes

Paul JC Hughes

POLARIS, Imaging Sciences, Department of Infection, Immunity and Cardiovascular Disease …
Verified email at sheffield.ac.uk
Cited by 818

Pulmonary MR angiography and perfusion imaging—a review of methods and applications

CS Johns, AJ Swift, PJC Hughes, Y Ohno… - European journal of …, 2017 - Elsevier
The pulmonary vasculature and its role in perfusion and gas exchange is an important
consideration in many conditions of the lung and heart. Currently the mainstay of imaging of the …

[HTML][HTML] Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study

…, JP Greenwood, S Plein, PJC Hughes… - The Lancet …, 2023 - thelancet.com
Introduction The multiorgan impact of moderate to severe coronavirus infections in the post-acute
phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan …

Lung perfusion: MRI vs. SPECT for screening in suspected chronic thromboembolic pulmonary hypertension

…, AJ Swift, S Rajaram, PJC Hughes… - Journal of Magnetic …, 2017 - Wiley Online Library
Purpose To assess the diagnostic accuracy of magnetic resonance imaging (MRI) perfusion
against perfusion single photon emission tomography (SPECT) screening for chronic …

Comparison of 3He and 129Xe MRI for evaluation of lung microstructure and ventilation at 1.5T

NJ Stewart, HF Chan, PJC Hughes… - Journal of magnetic …, 2018 - Wiley Online Library
Background To support translational lung MRI research with hyperpolarized 129 Xe gas,
comprehensive evaluation of derived quantitative lung function measures against established …

Spatial fuzzy c‐means thresholding for semiautomated calculation of percentage lung ventilated volume from hyperpolarized gas and 1H MRI

PJC Hughes, FC Horn, GJ Collier… - Journal of Magnetic …, 2018 - Wiley Online Library
Purpose To develop an image‐processing pipeline for semiautomated (SA) and
reproducible analysis of hyperpolarized gas lung ventilation and proton anatomical magnetic …

Dissolved 129Xe lung MRI with four‐echo 3D radial spectroscopic imaging: Quantification of regional gas transfer in idiopathic pulmonary fibrosis

GJ Collier, JA Eaden, PJC Hughes… - Magnetic …, 2021 - Wiley Online Library
Purpose Imaging of the different resonances of dissolved hyperpolarized xenon‐129 ( 129
Xe) in the lung is performed using a four‐echo flyback 3D radial spectroscopic imaging …

[HTML][HTML] Large-scale investigation of deep learning approaches for ventilated lung segmentation using multi-nuclear hyperpolarized gas MRI

JR Astley, AM Biancardi, PJC Hughes, H Marshall… - Scientific Reports, 2022 - nature.com
Respiratory diseases are leading causes of mortality and morbidity worldwide. Pulmonary
imaging is an essential component of the diagnosis, treatment planning, monitoring, and …

Patterns of regional lung physiology in cystic fibrosis using ventilation magnetic resonance imaging and multiple-breath washout

…, GJ Collier, H Marshall, PJC Hughes… - European …, 2018 - Eur Respiratory Soc
Hyperpolarised helium-3 ( 3 He) ventilation magnetic resonance imaging (MRI) and multiple-breath
washout (MBW) are sensitive methods for detecting lung disease in cystic fibrosis (…

The assessment of short-and long-term changes in lung function in cystic fibrosis using 129Xe MRI

LJ Smith, A Horsley, J Bray, PJC Hughes… - European …, 2020 - Eur Respiratory Soc
Introduction Xenon-129 ( 129 Xe) ventilation magnetic resonance imaging (MRI) is sensitive
to detect early cystic fibrosis (CF) lung disease and response to treatment. Xe-MRI could …

Assessment of the influence of lung inflation state on the quantitative parameters derived from hyperpolarized gas lung ventilation MRI in healthy volunteers

PJC Hughes, L Smith, HF Chan… - Journal of Applied …, 2019 - journals.physiology.org
In this study, the effect of lung volume on quantitative measures of lung ventilation was
investigated using MRI with hyperpolarized 3 He and 129 Xe. Six volunteers were imaged with …