User profiles for Paul G. Williams
Paul F WilliamsAssociate professor University of Sydney Verified email at sydney.edu.au Cited by 7785 |
[HTML][HTML] Haemodynamic definitions and updated clinical classification of pulmonary hypertension
…, MA Gatzoulis, M Krowka, PG Williams… - European respiratory …, 2019 - Eur Respiratory Soc
Since the 1st World Symposium on Pulmonary Hypertension (WSPH) in 1973, pulmonary
hypertension (PH) has been arbitrarily defined as mean pulmonary arterial pressure (mPAP) ≥…
hypertension (PH) has been arbitrarily defined as mean pulmonary arterial pressure (mPAP) ≥…
[HTML][HTML] Comprehensive evaluation of the 5XFAD mouse model for preclinical testing applications: a MODEL-AD study
…, RS Pandey, D Garceau, HM Williams… - Frontiers in aging …, 2021 - frontiersin.org
The ability to investigate therapeutic interventions in animal models of neurodegenerative
diseases depends on extensive characterization of the model(s) being used. There are …
diseases depends on extensive characterization of the model(s) being used. There are …
[PDF][PDF] Dorsal horn circuits for persistent mechanical pain
C Peirs, SPG Williams, X Zhao, CE Walsh, JY Gedeon… - Neuron, 2015 - cell.com
Persistent mechanical hypersensitivity that occurs in the setting of injury or disease remains
a major clinical problem largely because the underlying neural circuitry is still not known. …
a major clinical problem largely because the underlying neural circuitry is still not known. …
[PDF][PDF] Mechanical allodynia circuitry in the dorsal horn is defined by the nature of the injury
C Peirs, SPG Williams, X Zhao, CM Arokiaraj… - Neuron, 2021 - cell.com
The spinal dorsal horn is a major site for the induction and maintenance of mechanical allodynia,
but the circuitry that underlies this clinically important form of pain remains unclear. The …
but the circuitry that underlies this clinically important form of pain remains unclear. The …
Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity
…, DC Rees, M Reule, D Tisi, G Williams… - Journal of medicinal …, 2009 - ACS Publications
Here, we describe the identification of a clinical candidate via structure-based optimization
of a ligand efficient pyrazole-benzimidazole fragment. Aurora kinases play a key role in the …
of a ligand efficient pyrazole-benzimidazole fragment. Aurora kinases play a key role in the …
Functional connectomics spanning multiple areas of mouse visual cortex
To understand the brain we must relate neurons’ functional responses to the circuit architecture
that shapes them. Here, we present a large functional connectomics dataset with dense …
that shapes them. Here, we present a large functional connectomics dataset with dense …
[HTML][HTML] Structural and enzyme kinetic studies of retrograded starch: Inhibition of α-amylase and consequences for intestinal digestion of starch
Retrograded starch is known to be resistant to digestion. We used enzyme kinetic
experiments to examine how retrogradation of starch affects amylolysis catalysed by porcine …
experiments to examine how retrogradation of starch affects amylolysis catalysed by porcine …
Human diabetic neovascular membranes contain high levels of urokinase and metalloproteinase enzymes.
…, RR Ober, E DeJuan, GA Williams… - … & visual science, 1999 - iovs.arvojournals.org
PURPOSE: Retinal neovascularization is one of the leading causes of blindness. A crucial
event in this process is the remodeling and penetration of the capillary basement membrane …
event in this process is the remodeling and penetration of the capillary basement membrane …
Absorption of non-haem iron from food during normal pregnancy
JFR Barrett, PG Whittaker, JG Williams, T Lind - Bmj, 1994 - bmj.com
Objective: To determine whether the increased iron demands of pregnancy could be met by
increased absorption from dietary sources. Design and setting: Longitudinal prospective …
increased absorption from dietary sources. Design and setting: Longitudinal prospective …
Specimen collection: an essential tool
COLLECTING BIOLOGICAL specimens for scientific studies came under scrutiny when BA
Minteer et al.[“Avoiding (re) extinction,” Perspectives, 18 April, p. 260] suggested that this …
Minteer et al.[“Avoiding (re) extinction,” Perspectives, 18 April, p. 260] suggested that this …