Sarcoidosis is a multi-system disease of unknown etiology characterized by the formation of
granulomas in various organs. It affects people of all ethnic backgrounds and occurs at any …

On the basis of preclinical studies that show overexpression of class III β-tubulin is associated
with resistance to tubulin-binding agents, several investigators have addressed the …

Bourbon et al describe a series of 19 patients from France with VEXAS syndrome, including
a novel genetic aberration in UBA1, and the outcomes of treatment for those with and those …

IgG4-related systemic disease is now recognized as a systemic disease that may affect
various organs. The diagnosis is usually made in patients who present with elevated IgG4 in …

The treatment of advanced non-small-cell lung cancer (NSCLC is based on the combination
of platin and one of the following agents: taxanes, gemcitabine, vinorelbine or irinotecan. …

Both fundamental and clinical studies suggest that class III β-tubulin expression is associated
with resistance to taxanes and constitutes a prognostic factor in several solid tumors. In this …

Cytokines play a central role in the pathophysiology of autoimmune and inflammatory diseases.
Several cytokines signal through the JAK-STAT pathway, which is now recognized as a …

Topic An international, expert-led consensus initiative to develop systematic, evidence-based
recommendations for the treatment of noninfectious uveitis in the era of biologics. Clinical …

Objective To report the efficacy and safety of anti-TNF agents in patients with severe and/or
refractory manifestations of Behçet's disease (BD). Methods We performed a multicenter …

The large subunit of human ribonucleotide reductase, RRM1, is involved in the regulation of
cell proliferation, cell migration, tumour and metastasis development, and the synthesis of …