Increased systemic inflammation is a risk factor for COPD exacerbations

…, DS Postma, WCJ Hop, PLML Wielders… - Chest, 2008 - Elsevier
Background COPD is characterized by episodic increases in respiratory symptoms, so-called
exacerbations. COPD exacerbations are associated with an increase in local and systemic …

A new class of bronchodilator improves lung function in COPD: a trial with GSK961081

PLML Wielders, A Ludwig-Sengpiel… - European …, 2013 - Eur Respiratory Soc
GSK961081 is a bifunctional molecule demonstrating both muscarinic antagonist and β-agonist
activities. This was a 4-week, multicentre, randomised, double-blind, double-dummy, …

Surgical mediastinal staging in daily practice

…, MLG Janssen-Heijnen, PLML Wielders… - Lung Cancer, 2005 - Elsevier
STUDY OBJECTIVES:: An adequately staged mediastinum remains obligatory in patients
with NSCLC prior to surgery. In this study, we investigated the accuracy of preoperative …

Effect of once-daily fluticasone furoate/vilanterol versus vilanterol alone on bone mineral density in patients with COPD: a randomized, controlled trial

…, I Schenkenberger, PLML Wielders… - Therapeutic …, 2020 - journals.sagepub.com
Background: The relationship between inhaled corticosteroids and bone mineral density (BMD)
remains uncertain despite extensive research. Methods: This was an international, …

ERS Congress highlight: educational forum on continuing professional development

…, A Farr, M Allen, JG Guiral, PLML Wielders… - Breathe, 2018 - Eur Respiratory Soc
Each year as part of its International Congress, the European Respiratory Society (ERS)
dedicates a session to discuss the key themes in medical education affecting respiratory …

[HTML][HTML] Efficacy of formoterol Turbuhaler in the emergency treatment of patients with obstructive airway diseases

KM van den Broek, PLML Wielders, JPHM Creemers… - Respiratory …, 2008 - Elsevier
Dry powder devices are rarely used in the emergency room (ER) treatment of acute and
severe bronchoconstriction due to hesitations with respect to clinical efficacy. This study …

Endoscopic Treatment of Bronchial Lipoma: Two Case Reports

JHGM Willems, PLML Wielders, NJM Cox… - … of Bronchology & …, 2001 - journals.lww.com
Endobronchial lipomas are rare but offer possibilities for local—ie, endoscopic—treatment.
Two cases of bronchial lipoma are presented to demonstrate the diagnostic difficulties and …

A dual-acting muscarinic antagonist, ß2-agonist [MABA] molecule (GSK961081) improves lung function in COPD. A randomised trial

PLML Wielders, A Ludwig-Sengpiel, NW Locantore… - 2012 - Eur Respiratory Soc
Introduction GSK961081 is a dual pharmacophore demonstrating both muscarinic antagonist
and beta agonist activities in one molecule (MABA). Recent COPD treatment guidelines …

[PDF][PDF] Increased Exhalation of Hydr

…, LPHJ AARTS, PLML WIELDERS… - AM J RESPIR CRIT …, 1996 - researchgate.net
An imbalance between oxidative stress and antioxidative capacity is thought to play an
important role in the development and progression of chronic obstructive pulmonary disease (…

[PDF][PDF] Maryska LG Janssen-Heijnen, Pascal LML Wielders Dirk RAJ de Munck 2, Pieter E Postmus 3

SA Smulders, FWJM Smeenk - Patients with Resectable Lung Cancer …, 2005 - core.ac.uk
NSCLC prior to surgery. In this study, we investigated the accuracy of preoperative surgical
mediastinal staging procedures in 4 hospitals. Setting: Non-university teaching hospital and …