Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expression
Adaptation to hypoxia involves hypoxia-inducible transcription factors (HIFs) and requires
reprogramming of cellular metabolism that is essential during both physiological and …
reprogramming of cellular metabolism that is essential during both physiological and …
Bortezomib represses HIF-1α protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells
Bortezomib represents the first proteasome inhibitor (PI) with demonstrated antitumor
activity in the clinical setting, particularly for treatment of hematological malignancies. At the …
activity in the clinical setting, particularly for treatment of hematological malignancies. At the …
Cobalt induces hypoxia-inducible factor-1α (HIF-1α) in HeLa cells by an iron-independent, but ROS-, PI-3K-and MAPK-dependent mechanism
A Triantafyllou, P Liakos, A Tsakalof… - Free radical …, 2006 - Taylor & Francis
The iron-chelator desferrioxamine (DFO) and the transition metal cobalt induce hypoxia-inducible
factor-1α (HIF-1α) in normoxia. DFO stabilizes HIF-1α from proteolysis by inhibiting the …
factor-1α (HIF-1α) in normoxia. DFO stabilizes HIF-1α from proteolysis by inhibiting the …
The role of hypoxia‐inducible factor‐2 alpha in angiogenesis
Angiogenesis is a key enabling feature of mammalian embryonic development and tumor
progression, which provides oxygen and nutrients that are required for vessel growth and …
progression, which provides oxygen and nutrients that are required for vessel growth and …
Chimp: efficient lossless floating point compression for time series databases
P Liakos, K Papakonstantinopoulou… - Proceedings of the VLDB …, 2022 - dl.acm.org
Applications in diverse domains such as astronomy, economics and industrial monitoring,
increasingly press the need for analyzing massive collections of time series data. The sheer …
increasingly press the need for analyzing massive collections of time series data. The sheer …
Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells
Hypoxia-inducible factors (HIFs) are transcriptional regulators that mediate the cellular
response to low oxygen. Although HIF-1 is usually considered as the principal mediator of …
response to low oxygen. Although HIF-1 is usually considered as the principal mediator of …
Sim-piece: highly accurate piecewise linear approximation through similar segment merging
Approximating series of timestamped data points using a sequence of line segments with a
maximum error guarantee is a fundamental data compression problem, termed as piecewise …
maximum error guarantee is a fundamental data compression problem, termed as piecewise …
HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion in liver cancer cells under hypoxia
Hypoxia inducible factor 2 (HIF-2) is a transcriptional activator implicated in the cellular response
to hypoxia. Regulation of its inducible subunit, HIF-2α (also known as EPAS1), involves …
to hypoxia. Regulation of its inducible subunit, HIF-2α (also known as EPAS1), involves …
[HTML][HTML] ADORA2A rs5760423 and CYP1A2 rs762551 Polymorphisms as Risk Factors for Parkinson's Disease
Background: Parkinson’s disease (PD) is the second commonest neurodegenerative
disease. The genetic basis of PD is indisputable. Both ADORA2A rs5760423 and CYP1A2 …
disease. The genetic basis of PD is indisputable. Both ADORA2A rs5760423 and CYP1A2 …
ERK1/2 phosphorylates HIF-2α and regulates its activity by controlling its CRM1-dependent nuclear shuttling
Hypoxia-inducible factor 2 (HIF-2) is a principal component of the cellular response to oxygen
deprivation (hypoxia). Its inducible subunit, HIF-2α (also known as EPAS1), is controlled …
deprivation (hypoxia). Its inducible subunit, HIF-2α (also known as EPAS1), is controlled …