Incidence of venous thromboembolism in hospitalized patients with COVID‐19

…, J Heijmans, LP Smits, PI Bonta… - … of Thrombosis and …, 2020 - Wiley Online Library
Background Coronavirus disease 2019 (COVID‐19) can lead to systemic coagulation
activation and thrombotic complications. Objectives To investigate the incidence of objectively …

High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages

…, L Mes, M Steenhuis, GR Griffith, PI Bonta… - Science translational …, 2021 - science.org
Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily
around the time of activation of the adaptive immune response. Here, we provide evidence …

Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses

PI Bonta, CM Van Tiel, M Vos, TWH Pols… - … , and vascular biology, 2006 - Am Heart Assoc
Objective— Atherosclerosis is an inflammatory disease in which macrophage activation and
lipid loading play a crucial role. In this study, we investigated expression and function of the …

Bronchial thermoplasty in severe asthma: best practice recommendations from an expert panel

PI Bonta, P Chanez, JT Annema, PL Shah, R Niven - Respiration, 2018 - karger.com
… 35 d’Hooghe JNS, Goorsenberg AWM, de Bruin DM, Roelofs J, Annema JT, Bonta PI:
Optical coherence tomography for identification and quantification of human airway wall layers. …

[HTML][HTML] Emerging understanding of the mechanism of action of bronchial thermoplasty in asthma

…, EJM Weersink, PJ Sterk, JT Annema, PI Bonta - Pharmacology & …, 2018 - Elsevier
Bronchial Thermoplasty (BT) is an endoscopic treatment for moderate-to-severe asthma
patients who are uncontrolled despite optimal medical therapy. Effectiveness of BT has been …

Anti–MCP-1 gene therapy inhibits vascular smooth muscle cells proliferation and attenuates vein graft thickening both in vitro and in vivo

A Schepers, D Eefting, PI Bonta… - … , and vascular biology, 2006 - Am Heart Assoc
Objective— Because late vein graft failure is caused by intimal hyperplasia (IH) and accelerated
atherosclerosis, and these processes are thought to be inflammation driven, influx of …

Endobronchial ultrasound for the diagnosis of centrally located lung tumors: a systematic review and meta-analysis

…, F Leoncini, LC Crombag, R Spijker, PI Bonta… - Respiration, 2020 - karger.com
Bonta reports grants and other support from Boston Scientific, other from COOK, other from
Nuvaira, other from Pentax, non-financial support from Olympus, grants from St Jude Mecial. …

Imatinib in patients with severe COVID-19: a randomised, double-blind, placebo-controlled, clinical trial

…, PM Bet, W Boersma, PI Bonta… - The Lancet …, 2021 - thelancet.com
Background The major complication of COVID-19 is hypoxaemic respiratory failure from
capillary leak and alveolar oedema. Experimental and early clinical data suggest that the …

Eosinophils capture viruses, a capacity that is defective in asthma

…, BS Dierdorp, T Dekker, EP Hoefsmit, PI Bonta… - Allergy, 2019 - Wiley Online Library
Background Activated eosinophils cause major pathology in stable and exacerbating asthma;
however, they can also display protective properties like an extracellular antiviral activity. …

Bronchial thermoplasty induced airway smooth muscle reduction and clinical response in severe asthma. The TASMA randomized trial

…, EH Bel, PL Shah, JT Annema, PI Bonta - American journal of …, 2021 - atsjournals.org
… Goorsenberg AWM, d’Hooghe JNS, Slats AM, van den Aardweg JG, Annema JT, Bonta PI.
Resistance of the respiratory system measured with forced oscillation technique (FOT) …