The human lung is exposed to a large number of airborne pathogens as a result of the daily
inhalation of 10,000 litres of air. The observation that respiratory infections are nevertheless …

… Support statement: PS Hiemstra was supported by grants from the Lung Foundation Netherlands
(Amersfoot, the Netherlands), Grifols (Frankfurt am Main, Germany) and Galapagos NV …

It is increasingly recognized that the ubiquity of convenient single-use plastic has resulted in
a global plastic pollution challenge, with substantial environmental and health …

Cathelicidins are a family of antimicrobial proteins found in the peroxidase-negative granules
of neutrophils. The known biologic functions reside in the C-terminus, which must be …

Antimicrobial peptides are effector molecules of the innate immune system and contribute to
host defense and regulation of inflammation. The human cathelicidin antimicrobial peptide …

The reported requirement of functional Toll-like receptor (TLR) 4 for resistance to Gram-negative
pyelonephritis prompted us to localize the expression of TLR2 and TLR4 mRNA in the …

Cigarette smoking results in oxidative stress and inflammation in the lungs, which are
involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). 4-Hydroxy-2-…

Antimicrobial peptides produced by epithelial cells and neutrophils represent essential
elements of innate immunity, and include the defensin and cathelicidin family of antimicrobial …

Brown adipose tissue (BAT) combusts high amounts of fatty acids, thereby lowering plasma
triglyceride levels and reducing obesity. However, the precise role of BAT in plasma …

Antileukoprotease (ALP), or secretory leukocyte proteinase inhibitor, is an endogenous
inhibitor of serine proteinases that is present in various external secretions. ALP, one of the …