… Evidence for the involvement of MMP in the altered growth of ASM cells comes from studies
by Johnson and Knox, 19 where they demonstrated an antiproliferative effect of protease …

Increased airway smooth muscle (ASM) within the bronchial wall of asthmatic patients has
been well documented and is likely to be the result of increased muscle proliferation. We have …

Background Increased airway smooth muscle bulk is a pathological feature of asthma.
Asthma is well controlled by the combined inhalation of glucocorticoids and β 2 -adrenoceptor …

Background Increased proliferation of bronchial smooth-muscle cells may lead to increased
muscle mass in the airways of patients with asthma. The antiproliferative effect of …

BACKGROUND: Airway remodeling is a key feature of persistent asthma and includes
alterations in the extracellular matrix protein profile around the airway smooth muscle (ASM) and …

Airway remodeling is a key feature of persistent asthma. Part of the remodeling process
involves the laying down of extracellular matrix (ECM) proteins within the airways. In this study …

The airway smooth muscle cell has a variety of properties, which confer on it the ability to
participate actively in the inflammatory process and the remodeling events, which accompany …

… Studies by Johnson and Knox [24] have provided evidence for the involvement of MMPs
in the altered growth of ASM cells. In these studies, it was demonstrated in human ASM cells …

Hyperplasia of airway smooth muscle (ASM) within the bronchial wall of asthmatic patients
has been well documented and is likely due to increased muscle proliferation. We have …

There is strong evidence to implicate transforming growth factor-β in the remodeling that
occurs in asthma, as levels are increased in bronchial lavage fluid and gene expression is …