[HTML][HTML] The influence of a family history of asthma and parental smoking on airway responsiveness in early infancy

S Young, PN Le Souëf, GC Geelhoed… - … England Journal of …, 1991 - Mass Medical Soc
Background. Airway responsiveness to inhaled nonspecific bronchoconstrictive agents has
been demonstrated in normal, healthy infants. However, it is unknown whether airway …

Association between human rhinovirus C and severity of acute asthma in children

…, J Goldblatt, JE Gern, PN Le Souëf - European …, 2011 - Eur Respiratory Soc
A new and potentially more pathogenic group of human rhinovirus (HRV), group C (HRVC),
has recently been discovered. We hypothesised that HRVC would be present in children …

Lung function trajectories from pre-school age to adulthood and their associations with early life factors: a retrospective analysis of three population-based birth cohort …

…, JA Curtin, IE Buchan, PN Le Souëf… - The Lancet …, 2018 - thelancet.com
Background Maximal lung function in early adulthood is an important determinant of mortality
and COPD. We investigated whether distinct trajectories of lung function are present during …

The relationship between infant airway function, childhood airway responsiveness, and asthma

…, J Goldblatt, LI Landau, PN Le Souëf - American journal of …, 2004 - atsjournals.org
The relationship between reduced pulmonary function in early life and persistent wheeze (PW)
in school-aged children remains uncertain. In this study, V̇maxFRC was assessed at 1 …

Airway responsiveness in early infancy predicts asthma, lung function, and respiratory symptoms by school age

…, PR Burton, LI Landau, PN LeSOUËF - American Journal of …, 2001 - atsjournals.org
Asthma is the most common chronic childhood disease in developed nations. Little is known
about the relationship between airway responsiveness in infancy and the development of …

Human rhinovirus species C infection in young children with acute wheeze is associated with increased acute respiratory hospital admissions

…, JE Gern, IA Laing, PN Le Souëf - American journal of …, 2013 - atsjournals.org
Rationale: Human rhinovirus species C (HRV-C) is the most common cause of acute
wheezing exacerbations in young children presenting to hospital, but its impact on subsequent …

The transient value of classifying preschool wheeze into episodic viral wheeze and multiple trigger wheeze

…, OEM Savenije, PD Sly, PN Le Souef… - Acta …, 2010 - Wiley Online Library
Background: A recently proposed method for classifying preschool wheeze is to describe it as
either episodic (viral) wheeze or multiple trigger wheeze. In research studies, phenotype is …

IgE and IgG anti–house dust mite specificities in allergic disease

…, IA Laing, CM Hayden, J Goldblatt, PN Le Souëf… - Journal of Allergy and …, 2006 - Elsevier
BACKGROUND: There are few studies that quantitatively compare IgE and IgG antibody
binding to the major and minor house dust mite allergens. OBJECTIVE: To measure the IgE and …

Association between plasma CC16 levels, the A38G polymorphism, and asthma

…, PR Burton, J Goldblatt, PN Le Souef - American journal of …, 2000 - atsjournals.org
LE SOUËFLE SOUËF … Laing IA, Hermans C, Bernard A, Burton PR, Goldblatt J, Le
Souëf PN. Association between plasma CC16 levels, the A38G polymorphism, and asthma. …

Evaluation of SaO2 as a predictor of outcome in 280 children presenting with acute asthma

GC Geelhoed, LI Landau, PN Le Souëf - Annals of emergency medicine, 1994 - Elsevier
Study objectives: To evaluate the initial measurement of arterial oxygen saturation (SaO 2 )
as a predictor of outcome in acute childhood asthma compared with other factors of past and …