The deletion of Phe508 (ΔF508) in the first nucleotide binding domain (NBD1) of CFTR is
the most common mutation associated with cystic fibrosis. The ΔF508‐CFTR mutant is …

One of the major therapeutic strategy in cystic fibrosis aims at developing modulators of cystic
fibrosis transmembrane conductance regulator (CFTR) channels. We recently discovered …

Cystic fibrosis (CF) is a major inherited disorder involving abnormalities of fluid and
electrolyte transport in a number of different organs due to abnormal function of cystic fibrosis …

… Values of P<0.05 were considered as statistically significant: *P<0.05; **… Cordi and P.
Bonnette for access to non-cystic fibrosis and cystic fibrosis human lung samples, respectively. This …

The cystic fibrosis transmembrane conductance regulator (CFTR) gets activated via the
cAMP signaling pathway and is present in various secretory epithelial cells, including …

Cystic fibrosis is a genetic disease caused by mutations in the CFTR (cystic fibrosis transmembrane
conductance regulator) gene that affect transcription, folding, trafficking, degradation…

In the study of previously reported modulators of CFTR chloride channels that are cyclic
methylglyoxal (MG) diadducts (CMGD) to aromatic α-aminoazaheterocycles, we optimized a …

Introduction ENaC and CFTR are coexpressed in epithelia and have positive or negative
functional interactions. In addition, ENaC and CFTR promote migration in placental …

Cystic Fibrosis (CF) is a lethal, genetic disease caused by mutations to the CFTR chloride
channel. The most common CF causing mutation is the deletion of F508 from the first …

Cystic fibrosis transmembrane conductance regulator (CFTR) is the main chloride channel
present in the apical membrane of epithelial cells and the F508 deletion (F508del-CFTR) in …