Improved health outcomes in patients with COPD during 1 yr's treatment with tiotropium

…, S Kesten, L Korducki, PJG Cornelissen - European …, 2002 - Eur Respiratory Soc
Tiotropium, a novel once-daily inhaled anticholinergic, has been shown to improve lung
function over a 24-h period. In order to extend these findings, health-outcomes were evaluated …

Comparison of tiotropium once daily, formoterol twice daily and both combined once daily in patients with COPD

…, B Disse, A Mueller, PJG Cornelissen - European …, 2005 - Eur Respiratory Soc
This study compared the bronchodilator effects of tiotropium, formoterol and both combined
in chronic obstructive pulmonary disease (COPD). A total of 71 COPD patients (mean forced …

Effects of tiotropium with and without formoterol on airflow obstruction and resting hyperinflation in patients with COPD

…, J Verhaert, JJ Smeets, A Mueller, PJG Cornelissen - Chest, 2006 - Elsevier
Background The combination of short-acting β 2 -agonists and anticholinergics in the treatment
of COPD has been well documented, but data on combination of long-acting agents are …

A randomised controlled comparison of tiotropium and ipratropium in the treatment of chronic obstructive pulmonary disease

…, TA Bantje, ME Eland, L Korducki, PJG Cornelissen - Thorax, 2000 - thorax.bmj.com
BACKGROUND A study was undertaken to evaluate and compare the efficacy and safety of
tiotropium and ipratropium during long term treatment in patients with stable chronic …

[HTML][HTML] The efficacy of tiotropium administered via Respimat® Soft Mist™ Inhaler or HandiHaler® in COPD patients

JA Van Noord, PJG Cornelissen, JL Aumann, J Platz… - Respiratory …, 2009 - Elsevier
BACKGROUND: Tiotropium, a once daily inhaled anticholinergic delivered via HandiHaler ®
, provides bronchodilation for >24h and improves patient-centred outcomes. The Respimat …

[HTML][HTML] Combining tiotropium and salmeterol in COPD: effects on airflow obstruction and symptoms

…, JJ Smeets, J Zaagsma, A Mueller, PJG Cornelissen - Respiratory …, 2010 - Elsevier
BACKGROUND: Clinical information on 24-h spirometric efficacy of combining tiotropium and
salmeterol compared to single-agent therapy is lacking in patients with COPD. METHODS: …

24-hour bronchodilation following a single dose of the novel β2-agonist olodaterol in COPD

…, A Pivovarova, AL Hamilton, PJG Cornelissen - Pulmonary …, 2011 - Elsevier
BACKGROUND: Current guidelines recommend long-acting bronchodilators as maintenance
therapy in COPD when symptoms are not adequately controlled with short-acting agents. …

Pharmacokinetics and pharmacodynamics of tiotropium solution and tiotropium powder in chronic obstructive pulmonary disease

…, JA Van Noord, PJG Cornelissen… - The Journal of …, 2014 - Wiley Online Library
PJG Cornelissen PhD… PJG Cornelissen PhD … PJG Cornelissen PhD …

Pharmacodynamic steady state of tiotropium in patients with chronic obstructive pulmonary disease

…, L Korducki, PJG Cornelissen - European …, 2002 - Eur Respiratory Soc
Tiotropium (Spiriva®) is a new once-daily inhaled anticholinergic that has its effect through
prolonged muscarinic (M) 3 receptor antagonism. It has a clinically documented, long …

Pharmacokinetics of ipratropium bromide after single dose inhalation and oral and intravenous administration

…, GD Nossent, GH Koeter, PJG Cornelissen - European journal of …, 1989 - Springer
Single doses of ipratropium bromide were administered intravenously, orally and by slow
inhalation to ten healthy male volunteers. The plasma level after oral administration followed a …