This review describes production and effects of reactive oxygen species (ROS) on airway
function. ROS are important in many physiological processes but can also have detrimental …

… Immune cell adhesion to endothelial cells is mediated by adhesion molecules expressed
on immune cells and endothelial cells, eg P-, E- and L-selectins, β 1 - and β 2 -intergrins, …

The discovery that nitric oxide (NO) reacts with Superoxide (O 2 − ) forming peroxynitrite (ONOO
− ) (1) and the proof that this reaction occurs in vivo (2,3) holds enormous implications …

… < 0.001 compared with LPS or TNFα group; $ p < 0.05, $$ p < 0.01, $$$ p < 0.001 compared
with acetate alone group; & p < 0.05 compared with acetate in combination with GLPG/SHB …

… p < 0.05) compared with sham-treated mice and by 34% (p < 0.05) compared with mice
treated with 100 μg of OVA-IT alone (Fig. 3,F). In contrast, we found that the combination of 10 ng …

Objective Proline–glycine–proline (PGP) has been shown to have chemotactic effects on
neutrophils via CXCR2 in several lung diseases. PGP is derived from collagen by the …

The anti‐ICAM‐1 monoclonal antibody F10.2 was conjugated to liposomes to target to cells
expressing the cell adhesion molecule ICAM‐1. We demonstrate that F10.2 …

Background Tobacco smoking irritates and damages the respiratory tract and contributes to
a higher risk of developing lung emphysema. At present, smoking cessation is the only …

… ≤ 0.01 significantly different compared to control, # p ≤ 0.05, ## p ≤ 0.01 significantly
different compared to CSE and Ψ Ψ p ≤ 0.01 significantly different to LPS and Π p ≤ 0.05 …

Peroxynitrite (ONOO-) is a cytotoxic product of the rapid reaction between nitric oxide and
superoxide that may initiate inflammation. Isolated perfused tracheas from guinea pigs were …