User profiles for P. Donnelly
Dr Paul DonnellyGaelic Athletic Association Verified email at gaa.ie Cited by 1143 |
Copper complexes of bis (thiosemicarbazones): from chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals
BM Paterson, PS Donnelly - Chemical Society Reviews, 2011 - pubs.rsc.org
… his PhD in 2011 under the supervision of Dr Paul Donnelly. His doctoral research focused
on the synthesis … Brett is currently working in Dr Donnelly's lab as a post-doctoral researcher. …
on the synthesis … Brett is currently working in Dr Donnelly's lab as a post-doctoral researcher. …
[HTML][HTML] A systematic review of interventions to increase awareness of mental health and well-being in athletes, coaches and officials
Background The aim of the current study was to conduct a systematic review determining
the effect of sport-specific mental health awareness programs to improve mental health …
the effect of sport-specific mental health awareness programs to improve mental health …
Copper and Alzheimer's disease
Copper is essential for some of the enzymes that have a role in brain metabolism.
Sophisticated mechanisms balance copper import and export to ensure proper nutrient levels (…
Sophisticated mechanisms balance copper import and export to ensure proper nutrient levels (…
Increasing Cu bioavailability inhibits Aβ oligomers and tau phosphorylation
…, R Cappai, RA Cherny, PS Donnelly… - Proceedings of the …, 2009 - National Acad Sciences
Cognitive decline in Alzheimer's disease (AD) involves pathological accumulation of
synaptotoxic amyloid-β (Aβ) oligomers and hyperphosphorylated tau. Because recent evidence …
synaptotoxic amyloid-β (Aβ) oligomers and hyperphosphorylated tau. Because recent evidence …
Comparison of 64Cu-Complexing Bifunctional Chelators for Radioimmunoconjugation: Labeling Efficiency, Specific Activity, and in Vitro/in Vivo Stability
…, JD Williams, RL Paul, PS Donnelly… - Bioconjugate …, 2012 - ACS Publications
High radiolabeling efficiency, preferably to high specific activity, and good stability of the
radioimmunoconjugate are essential features for a successful immunoconjugate for imaging or …
radioimmunoconjugate are essential features for a successful immunoconjugate for imaging or …
Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label …
…, S Small, R Vaghasiya, M Armenis, P Donnelly… - The Lancet, 2019 - thelancet.com
Background Systolic blood pressure of more than 185 mm Hg is a contraindication to
thrombolytic treatment with intravenous alteplase in patients with acute ischaemic stroke, but the …
thrombolytic treatment with intravenous alteplase in patients with acute ischaemic stroke, but the …
The Alzheimer's therapeutic PBT2 promotes amyloid‐β degradation and GSK3 phosphorylation via a metal chaperone activity
…, MS Savva, LW Hung, PS Donnelly… - Journal of …, 2011 - Wiley Online Library
… Dashed line in panel (b) represents GSK3 activity in cell extracts measured by following the
incorporation of [ 32 P] from [ 32 P]-ATP into a synthetic GSK3 substrate. (c) Cell and media …
incorporation of [ 32 P] from [ 32 P]-ATP into a synthetic GSK3 substrate. (c) Cell and media …
Transfer of copper between bis (thiosemicarbazone) ligands and intracellular copper-binding proteins. Insights into mechanisms of copper uptake and hypoxia …
Z Xiao, PS Donnelly, M Zimmermann… - Inorganic …, 2008 - ACS Publications
Bis(thiosemicarbazonato) complexes Cu II (Btsc) have attracted interest as promising
metallodrugs and, in particular, as copper radiopharmaceuticals. Prototypes Cu(Atsm) and Cu(…
metallodrugs and, in particular, as copper radiopharmaceuticals. Prototypes Cu(Atsm) and Cu(…
[HTML][HTML] Selective intracellular release of copper and zinc ions from bis (thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-β peptide
PS Donnelly, A Caragounis, T Du, KM Laughton… - Journal of Biological …, 2008 - ASBMB
Copper and zinc play important roles in Alzheimer disease pathology with recent reports
describing potential therapeutics based on modulation of metal bioavailability. We examined …
describing potential therapeutics based on modulation of metal bioavailability. We examined …
[HTML][HTML] Metal complexes designed to bind to amyloid-β for the diagnosis and treatment of Alzheimer's disease
DJ Hayne, SC Lim, PS Donnelly - Chemical Society Reviews, 2014 - pubs.rsc.org
Alzheimer's disease is the most common form of age-related neurodegenerative dementia.
The disease is characterised by the presence of plaques in the cerebral cortex. The major …
The disease is characterised by the presence of plaques in the cerebral cortex. The major …