… PC Avila has consulting arrangements with Genentech and has received grant support
from Genentech, Novartis, GlaxoSmithKline, AstraZeneca, and Aventis. The rest of the authors …

The cause of chronic rhinosinusitis (CRS) remains unclear. Study of the genetic susceptibility
to CRS might be a valuable strategy to understand the pathogenesis of this burdensome …

The purpose of this review is to discuss recent findings made during studies of the upper
airways and sinuses of people with chronic rhinosinusitis (CRS) in the context of the literature. …

Asthma is a common disease with a complex risk architecture including both genetic and
environmental factors. We performed a meta-analysis of North American genome-wide …

The detection of viral pathogens is of critical importance in biology, medicine, and agriculture.
Unfortunately, existing techniques to screen for a broad spectrum of viruses suffer from …

Thymic stromal lymphopoietin (TSLP) is elevated in asthma and triggers dendritic cell-mediated
activation of Th2 inflammatory responses. Although TSLP has been shown to be …

Rationale: Independent replication of genetic associations in complex diseases, particularly
in whole-genome association studies, is critical to confirm the association. Objectives: A …

Background. Between 50% and 80% of asthma exacerbations are associated with viral
respiratory tract infections (RTIs), yet the influence of viral pathogen diversity on asthma …

Rationale: Air pollution is a known asthma trigger and has been associated with short-term
asthma symptoms, airway inflammation, decreased lung function, and reduced response to …

… Asthma was confirmed based on measurement of airway hyperresponsiveness (methacholine
PC 20 ≤8 mg/mL or FEV 1 improvement ≥12% after albuterol). At enrollment, asthmatic …