The increasing prevalence of heart failure poses enormous challenges for health care systems
worldwide. Despite effective medical interventions that target neurohumoral activation, …

… L, Ueland T, Fjeld J, Holt E, Gundersen T, Breivik K, Følling M, Hodt A, Skårdal R, Kjekshus
J, Andreassen AK, Kjekshus E, Wergeland R, Yndestad A, Frøland SS, Semb AG, Aukrust P: …

Patients with chronic heart failure (HF) are characterized by systemic inflammation, as
evident by raised circulating levels of several inflammatory cytokines with increasing levels …

… Comparing NASH with simple steatosis, levels of TNF-α (P=0.024) and CCL2/MCP-1 (P=0.012)
were elevated and adiponectin (in women) (P=0.001) were decreased also after …

… 2-tailed p values and values <0.05 were considered significant. However, particular attention
should be directed toward smaller p values <0.01, because a considerable number of p …

Background— Although the participation of inflammation in atherogenesis is widely recognized,
the identification of the different components has not been clarified. In particular, the role …

… Plasma levels of TMAO (P = 0.01), choline (P < 0.001) and betaine (P < 0.001) were … P
< 0.05, **P < 0.01, ***P < 0.001 versus healthy control subjects matched for age and sex; †P …

… Pål Aukrust … P<0.05 (2-sided) was considered significant. … P<0.05 versus controls, #P<0.05
versus patients with stable angina. Data are given as medians and ranges. …

… without respiratory failure (P = 0.008 and P = 0.034). Logistic regression showed increasing
odds of respiratory failure with sC5b-9 (odds ratio 31.9, 95% CI 1.4 to 746, P = 0.03) and …

Aims Nucleotide-binding oligomerization domain-Like Receptor with a Pyrin domain 3 (NLRP3)
is considered necessary for initiating a profound sterile inflammatory response. NLRP3 …