Background: In a substantial proportion of patients with crescentic glomerulonephritis (CGN),
both anti-glomerular basement membrane (GBM) antibodies and antineutrophil …

… produce a perinuclear staining pattern (P-ANCA) by IIF were … autoantigens for C-ANCA
and P-ANCA were identified as … aberrant P-ANCA pattern that is often referred to as atypical P…

… However, none of these had an odds ratio that was significant genome-wide (P value <5×10
−8 ). Lyons et al. found a higher prevalence of SERPINA1 polymorphisms in patients with …

… ) (P=0.77). Six of the 33 patients in the rituximab group (18%) and 2 of the 11 patients in
the control group (18%) died (P=1.00)… group and 15 ml per minute in the control group (P=0.14). …

… B cell counts fell in both groups (figure 2A) but fell further in the rituximab group at 6
months, p<0.01). All in the rituximab group (n=33) and one in the control group achieved B cell …

… P values less than 0.05 were considered significant. Statistical analyses were … (P = 0.06),
echocardiographic defects in 54% of CSS patients compared with 3% of control subjects (P < …

Background Vilobelimab, an anti-C5a monoclonal antibody, was shown to be safe in a
phase 2 trial of invasively mechanically ventilated patients with COVID-19. Here, we aimed to …

Background A novel autoinflammatory syndrome was recently described in male patients
who harbored somatic mutations in the X-chromosomal UBA1 gene. These patients were …

Background Severe COVID-19 is characterised by inflammation and coagulation in the
presence of complement system activation. We aimed to explore the potential benefit and safety …

Background Disease-specific studies have reported impaired humoral responses after
SARS-CoV-2 vaccination in patients with immune-mediated inflammatory disorders treated with …