Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma

…, RH Brown, V Brusasco, P Chitano… - European …, 2007 - Eur Respiratory Soc
… M/P ratio, the maximal mid-expiratory flow on a P and complete M expiratory flow volume curve
are compared. An M/P … An M/P ratio of <1 means that the deep inspiration decreased mid-…

Effect of oxidant air pollutants on the respiratory system: insights from experimental animal research

P Chitano, JJ Hosselet, CE Mapp… - European respiratory …, 1995 - Eur Respiratory Soc
In the present paper, we have reviewed experimental animal studies on the effects of the two
most important oxidant airborne pollutants, nitrogen dioxide and ozone, on the respiratory …

Mechanisms and pathology of occupational asthma

…, P Maestrelli, A Di Stefano, P Chitano… - European …, 1994 - Eur Respiratory Soc
Since the pathogenesis and the pathological features of occupational asthma are similar to
those of nonoccupational asthma, the former represents a very useful model for the …

Nox4 mediates TGF-β1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells

…, K Sanders, TM Murphy, P Chitano… - … of Physiology-Lung …, 2007 - journals.physiology.org
Transforming growth factor-β1 (TGF-β1) plays a pivotal role in increasing airway smooth
muscle mass in severe asthma by inducing proliferation and hypertrophy of human airway …

[HTML][HTML] Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans

…, D Taraskiewicz, B Bolaños, P Chitano… - The Journal of …, 2003 - Am Soc Clin Investig
… A P value of less than 0.05 was considered to be significant. For ex vivo phagocytosis,
mice were anesthetized with an intraperitoneal injection of 60 μl of xylazine/ketamine mixture, …

NADPH oxidase promotes NF-κB activation and proliferation in human airway smooth muscle

…, MT Quinn, TM Murphy, P Chitano… - … of Physiology-Lung …, 2002 - journals.physiology.org
Evidence is rapidly accumulating that low-activity-reduced nicotinamide adenine dinucleotide
phosphate (NADPH) oxidases homologous to that in phagocytic cells generate reactive …

On the terminology for describing the length-force relationship and its changes in airway smooth muscle

…, B Camoretti-Mercado, P Chitano… - Journal of applied …, 2004 - journals.physiology.org
The observation that the length-force relationship in airway smooth muscle can be shifted
along the length axis by accommodating the muscle at different lengths has stimulated great …

S-nitrosoglutathione inhibits α1-adrenergic receptor-mediated vasoconstriction and ligand binding in pulmonary artery

…, JS Stamler, TJ McMahon, P Chitano… - … of Physiology-Lung …, 2006 - journals.physiology.org
… The P values have been provided where statistical tests were performed. … 24 ± 10 7 pM in
treated, P > 0.05). An agonist competition curve with PE (10 −8 –10 −4 M) indicated only the low…

[HTML][HTML] Requirement for reactive oxygen species in serum-induced and platelet-derived growth factor-induced growth of airway smooth muscle

…, AR Whorton, TM Murphy, P Chitano… - Journal of Biological …, 1999 - ASBMB
Reactive oxygen species have been recently identified as important mediators of mitogenic
signaling in a number of cell types. We therefore explored their role in mediating mitogenesis …

Lung resistance and elastance are different in ex vivo sheep lungs ventilated by positive and negative pressures

SJ Dong, L Wang, P Chitano… - … of Physiology-Lung …, 2022 - journals.physiology.org
… The independent variable V is the airflow, V is the ventilation volume calculated from integrating
the flow signal, and P 0 is an offset pressure to set P tp = 0 when both V and V are zero. …