While tissue engineering is a promising alternative for treating critical-sized cranio-maxillofacial
bone defects, improvements in scaffold design are needed. In particular, scaffolds that …

Background Fetal alcohol exposure affects 1 in 100 children making it the leading cause of
mental retardation in the US. It has long been known that alcohol affects cerebellum …

In adult mammalian brains, neurogenesis persists in the subventricular zone of the lateral
ventricles (SVZ) and the dentate gyrus (DG) of the hippocampus. Although evidence suggest …

This review summarizes the mechanisms that control the activity of the c-Myb transcription
factor in normal cells and tumors, and discusses how c-Myb plays a role in the regulation of …

There is increasing concern that animal and human reproduction may be adversely affected
by exposure to xenoestrogens that activate estrogen receptors. There is evidence that one …

Synthetic matrices with dynamic presentation of cell guidance cues are needed for the
development of physiologically relevant in vitro tumor models. Towards the goal of mimicking …

Structural simplification of an antimitotic natural product podophyllotoxin with mimetic
heterocyclic scaffolds constructed using multicomponent reactions led to the identification of …

Repeated mechanical and chemical insults cause an irreversible alteration of extracellular
matrix (ECM) composition and properties, giving rise to vocal fold scarring that is refractory to …

Crosslinked, degradable, and cell-adhesive hydrogel microfibers were synthesized via
interfacial polymerization employing tetrazine ligation, an exceptionally fast bioorthogonal …

Formation of centromeric heterochromatin in fission yeast requires the combined action of
chromatin modifying enzymes and small RNAs derived from centromeric transcripts. Positive …