Human trachealis and main bronchi smooth muscle are normoresponsive in asthma

G Ijpma, L Kachmar, OS Matusovsky… - American journal of …, 2015 - atsjournals.org
Rationale: Airway smooth muscle (ASM) plays a key role in airway hyperresponsiveness (AHR)
but it is unclear whether its contractility is intrinsically changed in asthma. Objectives: To …

Millisecond conformational dynamics of skeletal myosin II power stroke studied by high-speed atomic force microscopy

OS Matusovsky, N Kodera, C MacEachen, T Ando… - ACS …, 2020 - ACS Publications
Myosin-based molecular motors are responsible for a variety of functions in the cells. Myosin
II is ultimately responsible for muscle contraction and can be affected by multiple mutations, …

Twitchin, a thick-filament protein from molluscan catch muscle, interacts with F-actin in a phosphorylation-dependent way

…, TV Permyakova, OS Matusovsky - Archives of Biochemistry …, 2004 - Elsevier
Twitchin belongs to the titin-like giant proteins family, it is co-localized with thick filaments in
molluscan catch muscles and regulates the catch state depending on its level of …

Intrapulmonary airway smooth muscle is hyperreactive with a distinct proteome in asthma

…, L Kachmar, A Panariti, OS Matusovsky… - European …, 2020 - Eur Respiratory Soc
Constriction of airways during asthmatic exacerbation is the result of airway smooth muscle (ASM)
contraction. Although it is generally accepted that ASM is hypercontractile in asthma, …

Peripheral airway smooth muscle, but not the trachealis, is hypercontractile in an equine model of asthma

OS Matusovsky, L Kachmar, G Ijpma… - American journal of …, 2016 - atsjournals.org
Heaves is a naturally occurring equine disease that shares many similarities with human
asthma, including reversible antigen-induced bronchoconstriction, airway inflammation, and …

High-speed AFM reveals subsecond dynamics of cardiac thin filaments upon Ca2+ activation and heavy meromyosin binding

OS Matusovsky, A Mansson… - Proceedings of the …, 2019 - National Acad Sciences
High-speed atomic force microscopy (HS-AFM) can be used to study dynamic processes with
real-time imaging of molecules within 1- to 5-nm spatial resolution. In the current study, we …

CD4+ T cells enhance the unloaded shortening velocity of airway smooth muscle by altering the contractile protein expression

OS Matusovsky, EM Nakada, L Kachmar… - The Journal of …, 2014 - Wiley Online Library
CD4+ T cells enhance the unloaded shortening velocity of airway smooth muscle by altering
the contractile protein expression - Matusovsky - 2014 - The Journal of Physiology - Wiley …

“Twitchin–actin linkage hypothesis” for the catch mechanism in molluscan muscles: Evidence that twitchin interacts with myosin, myorod, and paramyosin core and …

NS Shelud'ko, OS Matusovsky, TV Permyakova… - Archives of Biochemistry …, 2007 - Elsevier
“Twitchin–actin linkage hypothesis” for the catch mechanism in molluscan smooth muscles
postulates in vivo existence of twitchin links between thin and thick filaments that arise in a …

Contractile properties of intrapulmonary airway smooth muscle in cystic fibrosis

OS Matusovsky, L Kachmar, G Ijpma… - American journal of …, 2019 - atsjournals.org
Cystic fibrosis (CF) is an autosomal-recessive disease caused by mutations in the CF
transmembrane conductance regulator gene. Many patients with CF have asthma-like symptoms …

Ileal smooth muscle dysfunction and remodeling in cystic fibrosis

PA Risse, L Kachmar, OS Matusovsky… - American Journal …, 2012 - journals.physiology.org
Patients with cystic fibrosis (CF) often suffer from gastrointestinal cramps and intestinal
obstruction. The CF transmembrane conductance regulator (CFTR) channel has been shown to …