Rationale Custom-made mandibular advancement devices (MADs) are reported as providing
higher efficacy rates compared with thermoplastic heat-moulded MADs but at the price of …

Purpose Obstructive sleep apnea (OSA) has been described as a common sleep respiratory
disorder. Its prevalence in the adult population has been reported to be high, varying from 3…

A role for β-endorphin (β-END) in the pathophysiology of major depressive disorder (MDD)
is suggested by both animal research and studies examining clinical populations. The major …

Familial hypercholesterolaemia (FH) is a dominant and highly penetrant monogenic
disorder present from birth that markedly elevates plasma low-density lipoprotein (LDL)-cholesterol …

Previous genome-wide association studies (GWASs) of stroke — the second leading cause
of death worldwide — were conducted predominantly in populations of European ancestry 1 …

Background Direct-acting oral anticoagulant use for stroke prevention in atrial fibrillation is
limited by bleeding concerns. Asundexian, a novel, oral small molecule activated coagulation …

Teachers who strive for excellence will incorporate a vast array of behavior management
approaches in order that all children are engaged in a meaningful learning environment. …

A benign oropharyngial infection without appropriate treatment can be complicated by a
jugular vein thrombosis and disseminated septic embolies with deleterious pulmonary effects. …

Genetic risk information is relevant to individual patients and also their blood relatives.
Health practitioners (HPs) routinely advise patients of the importance of sharing genetic …

Basal-like breast cancer (BLBC) is a heterogeneous disease with poor prognosis; however,
its cellular origins and aetiology are poorly understood. In this study, we show that inhibitor …