The periaqueductal gray (PAG) plays a critical role in autonomic function and behavioural
responses to threatening stimuli. Recent evidence has revealed the PAG’s potential …

A person's expectations and mood are major contributors to the function of the brain
networks that generate perceptions of breathlessness. Breathlessness, therefore, arises from …

Background and aims: Currently there is considerable interest in ketone metabolism owing
to recently reported benefits of ketosis for human health. Traditionally, ketosis has been …

The brainstem is directly involved in controlling blood pressure, respiration, sleep/wake cycles,
pain modulation, motor, and cardiac output. As such it is of significant basic science and …

Breathlessness in chronic obstructive pulmonary disease (COPD) is often discordant with
airway pathophysiology (“over-perception”). Pulmonary rehabilitation profoundly affects …

The periaqueductal gray matter (PAG) is a midbrain structure, involved in key homeostatic
neurobiological functions, such as pain modulation and cardiorespiratory control. Animal …

10.7554/eLife.21749.001 Previously we observed differential activation in individual columns
of the periaqueductal grey (PAG) during breathlessness and its conditioned anticipation ( …

10.7554/eLife.12047.001 The sensation of breathlessness is the most threatening symptom
of respiratory disease. The different subdivisions of the midbrain periaqueductal gray (PAG) …

… Faull et al. [46] demonstrated that elevations in blood hydrogen ion (H + ) concentration
resulting from KE ingestion altered aspects of perceived exertion during exercise, increasing …

The periaqueductal grey (PAG) is a nucleus within the midbrain, and evidence from animal
models has identified its role in many homeostatic systems including respiration. Animal …