IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-γ production by the stress kinase p38 and by the extracellular …
U Kalina, D Kauschat, N Koyama… - The Journal of …, 2000 - journals.aai.org
IL-18 is a regulator of NK cell function which utilizes the serine-threonine IL-1R-associated
kinase signal transduction pathway and may activate additional not yet characterized …
kinase signal transduction pathway and may activate additional not yet characterized …
Receptor specificities of human respiroviruses
…, RA Scroggs, M Uchikawa, N Koyama… - Journal of …, 2001 - Am Soc Microbiol
Through their hemagglutinin-neuraminidase glycoprotein, parainfluenza viruses bind to sialic
acid-containing glycoconjugates to initiate infection. Although the virus-receptor interaction …
acid-containing glycoconjugates to initiate infection. Although the virus-receptor interaction …
Enhanced production of IL‐18 in butyrate‐treated intestinal epithelium by stimulation of the proximal promoter region
U Kalina, N Koyama, T Hosoda… - European journal of …, 2002 - Wiley Online Library
Expression of IL‐18 in intestinal epithelial cells (IEC) has been implicated in Th1 cell‐mediated
chronic intestinal inflammation and anti‐tumor immunity. However, physiological …
chronic intestinal inflammation and anti‐tumor immunity. However, physiological …
[HTML][HTML] Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes
C Sekine, A Koyanagi, N Koyama, K Hozumi… - Arthritis research & …, 2012 - Springer
Introduction Osteoclastogenesis plays an important role in the bone erosion of rheumatoid
arthritis (RA). Recently, Notch receptors have been implicated in the development of …
arthritis (RA). Recently, Notch receptors have been implicated in the development of …
Evidence for activation of nuclear factor kappaB in obstructive sleep apnea
…, M Yoshikawa, A Fukuoka, K Makinodan, N Koyama… - Sleep and …, 2006 - Springer
Obstructive sleep apnea (OSA) is a risk factor for atherosclerosis, and atherosclerosis evolves
from activation of the inflammatory cascade. We propose that activation of the nuclear …
from activation of the inflammatory cascade. We propose that activation of the nuclear …
Production of inflammatory mediators by monocytes in patients with obstructive sleep apnea syndrome
…, A Fukuoka, K Makinodan, N Koyama… - Internal …, 2009 - jstage.jst.go.jp
Background Obstructive sleep apnea syndrome (OSAS) is known to be a risk factor of
cardiovascular events. However, the precise mechanism linking the two has not been fully …
cardiovascular events. However, the precise mechanism linking the two has not been fully …
Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice
…, C Sekine, A Koyanagi, N Koyama… - International …, 2008 - academic.oup.com
Notch2 and Delta-like 1 (Dll1) have been implicated in the development of marginal zone B (MZB)
cells. In the present study, we characterized the expression and function of mouse …
cells. In the present study, we characterized the expression and function of mouse …
The SCFCdc4 ubiquitin ligase regulates calcineurin signaling through degradation of phosphorylated Rcn1, an inhibitor of calcineurin
…, A Ikeda, R Nagao, N Koyama - Proceedings of the …, 2007 - National Acad Sciences
The highly conserved RCN family of proteins regulates the serine/threonine protein
phosphatase calcineurin, which is required for the expression of genes involved in Ca 2+ -…
phosphatase calcineurin, which is required for the expression of genes involved in Ca 2+ -…
Effect of serum leptin levels on hypercapnic ventilatory response in obstructive sleep apnea
…, M Yoshikawa, A Fukuoka, S Tamaki, N Koyama… - Respiration, 2008 - karger.com
Background: Leptin levels have been reported to be higher in patients with obstructive
sleep apnea (OSA) than in control subjects with matching age and body mass index (BMI). …
sleep apnea (OSA) than in control subjects with matching age and body mass index (BMI). …
[HTML][HTML] Mesenchymal miR-21 regulates branching morphogenesis in murine submandibular gland in vitro
T Hayashi, N Koyama, Y Azuma, M Kashimata - Developmental biology, 2011 - Elsevier
Branching morphogenesis in murine submandibular glands (SMG) is regulated by growth
factors, extracellular matrix (ECM) and many biological processes through interactions …
factors, extracellular matrix (ECM) and many biological processes through interactions …