Cellular and molecular pathobiology of pulmonary arterial hypertension

…, EK Weir, O Eickelberg, NF Voelkel… - Journal of the American …, 2004 - jacc.org
Pulmonary arterial hypertension (PAH) has a multifactorial pathobiology. Vasoconstriction,
remodeling of the pulmonary vessel wall, and thrombosis contribute to increased pulmonary …

Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure

NF Voelkel, RA Quaife, LA Leinwand, RJ Barst… - Circulation, 2006 - Am Heart Assoc
Knowledge about the role of the right ventricle in health and disease historically has lagged
behind that of the left ventricle. Less muscular, restricted in its role to pumping blood through …

[HTML][HTML] Inhibition of VEGF receptors causes lung cell apoptosis and emphysema

…, PK Hirth, J Waltenberger, NF Voelkel - The Journal of …, 2000 - Am Soc Clin Investig
Pulmonary emphysema, a significant global health problem, is characterized by a loss of
alveolar structures. Because VEGF is a trophic factor required for the survival of endothelial …

Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension

…, L Wright, D Badesch, NF Voelkel - American journal of …, 1999 - atsjournals.org
Prostacyclin is a powerful vasodilator and inhibits platelet adhesion and cell growth. We
hypothesized that a decrease in expression of the critical enzyme PGI 2 synthase (PGI 2 -S) in …

Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death‐dependent pulmonary endothelial cell proliferation and severe pulmonary …

…, GMC MAHON, J Waltenberger, NF Voelkel… - The FASEB …, 2001 - Wiley Online Library
Our understanding of the pathobiology of severe pulmonary hypertension, usually a fatal
disease, has been hampered by the lack of information of its natural history. We have …

Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology

…, RJ Oudiz, S Provencher, A Torbicki, NF Voelkel… - Journal of the American …, 2013 - jacc.org
Survival in patients with pulmonary arterial hypertension (PAH) is closely related to right
ventricular (RV) function. Although pulmonary load is an important determinant of RV systolic …

Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension.

…, B Groves, DB Badesch, NF Voelkel - The American journal of …, 1994 - ncbi.nlm.nih.gov
The plexiform lesion in primary pulmonary hypertension is a glomeruloid structure forming
channels in branches of the pulmonary artery. These lesions have been considered an …

Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema

…, DA LYNCH, SC FLORES, NF VOELKEL - American journal of …, 2001 - atsjournals.org
Emphysema due to cigarette smoking is characterized by a loss of alveolar structures. We
hypothesize that the disappearance of alveoli involves apoptosis of septal endothelial cells …

Inflammation, growth factors, and pulmonary vascular remodeling

…, R Schermuly, KR Stenmark, NF Voelkel… - Journal of the american …, 2009 - jacc.org
Inflammatory processes are prominent in various types of human and experimental pulmonary
hypertension (PH) and are increasingly recognized as major pathogenic components of …

The right ventricle under pressure: cellular and molecular mechanisms of right-heart failure in pulmonary hypertension

HJ Bogaard, K Abe, AV Noordegraaf, NF Voelkel - Chest, 2009 - Elsevier
Pulmonary arterial hypertension (PAH) is a deadly disease in which vasoconstriction and
vascular remodeling both lead to a progressive increase in pulmonary vascular resistance. …