Peptide growth factors play an important role in several intracellular processes, such as
cellular growth and differentiation, angiogenesis and apoptosis, as well as in carcinogenesis, …

p53 codon 72 Arg homozygosity has been associated with increased risk of developing
cervical cancer. This association has been tested in various human cancers with controversial …

Purpose: The deleted in liver cancer-1 (DLC-1) gene that encodes a Rho GTPase-activating
protein with tumor suppressor function is located on chromosome 8p21-22, a region …

Abnormal apoptotic events in chronic obstructive pulmonary disease (COPD) subvert cellular
homeostasis and may play a primary role in its pathogenesis. However, studies in human …

In this study we examined by QRT-PCR the mRNA expression of TGF-β 1, IGF-1, EGF, FGF-2
and YY1 in human brain tumors. Our findings introduce YY1, for the first time, as a novel …

Genetic, immune and environmental interactions are key elements for the development of
COPD. Cigarette smoking is considered the primary risk factor initiating inflammatory …

Prohibitins (PHB1 and PHB2) are versatile proteins located at the inner mitochondrial
membrane, maintaining normal mitochondrial function and morphology. They interact with the …

Background Lung cytotoxic mechanisms trigger the release of perforin and granzymes,
causing oxidative DNA damage that ultimately leads to apoptosis. These effects, although …

BACKGROUND: The placental anticoagulant protein Annexin A5 (ANXA5) is highly expressed
on the apical surfaces of syncytiotrophoblasts and plays an important role in maintaining …

Preeclampsia (PE) is a major cause of maternal mortality and morbidity, affecting 3–5% of
all pregnancies. The Notch signaling pathway plays an important role during placental …