Angiogenesis assays: a critical overview

…, R Lewis, B Shinners, L Kubai, N Akhtar - Clinical …, 2003 - academic.oup.com
Background: Angiogenesis, the formation of new blood vessels, is an integral part of both
normal developmental processes and numerous pathologies, ranging from tumor growth and …

[HTML][HTML] Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

…, L Aitken, B Ajay, A Ajibode, A Ajmi, N Akhtar, N Akhtar… - The Lancet, 2021 - thelancet.com
Background In this study, we aimed to evaluate the effects of tocilizumab in adult patients
admitted to hospital with COVID-19 with both hypoxia and systemic inflammation. Methods This …

Angiogenesis assays: problems and pitfalls

R Auerbach, N Akhtar, RL Lewis… - Cancer and Metastasis …, 2000 - Springer
Many studies of angiogenesis inducers and inhibitors rely on in vitro or in vivo models as
indicators of efficacy. However, as valuable as these models are, there are limitations to each …

[HTML][HTML] In situ replacement of infected aortic grafts with rifampicin-bonded prostheses: the Leicester experience (1992 to 1998)

PD Hayes, A Nasim, NJM London, RD Sayers… - Journal of vascular …, 1999 - Elsevier
Purpose: Prosthetic graft infection after aortic aneurysm surgery is a life-threatening complication.
Treatment options include total graft excision and extra-anatomic bypass grafting or in …

[HTML][HTML] Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

…, B Ajay, A Ajibode, A Ajmi, MN Akhtar, N Akhtar… - The Lancet, 2021 - thelancet.com
Background Azithromycin has been proposed as a treatment for COVID-19 on the basis of its
immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in …

[HTML][HTML] Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

…, A Ajmi, T Akbar, N Akhtar, N Akhtar, N Akhtar… - The Lancet, 2021 - thelancet.com
Background Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2
antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma …

The sponge/Matrigel angiogenesis assay

N Akhtar, EB Dickerson, R Auerbach - Angiogenesis, 2002 - Springer
It has become increasingly clear that definitive tests for angiogenesis require in vivo assays.
Recently, the Matrigel plug assay has become the method of choice for many studies …

[HTML][HTML] Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

…, L Aitken, B Ajay, A Ajibode, A Ajmi, N Akhtar, N Akhtar… - The Lancet, 2022 - thelancet.com
Background Casirivimab and imdevimab are non-competing monoclonal antibodies that bind
to two different sites on the receptor binding domain of the SARS-CoV-2 spike glycoprotein…

Measurement of environmental radioactivity for estimation of radiation exposure from saline soil of Lahore, Pakistan

N Akhtar, M Tufail, M Ashraf, MM Iqbal - Radiation measurements, 2005 - Elsevier
Radioactivity, natural and man made, is omnipresent in the earth's crust in different amounts.
The soil on the earth's crust is a source of continuous exposure to human beings. The …

Measurement of terrestrial radiation for assessment of gamma dose from cultivated and barren saline soils of Faisalabad in Pakistan

M Tufail, N Akhtar, M Waqas - Radiation measurements, 2006 - Elsevier
Natural radioactivity originates from extraterrestrial sources as well as from primordial
radioactive elements in the earth crust. The amount of radioactivity in soil varies widely and is a …